dc.contributor.author | Ioannidou, Heraklidia A. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Ioannidou, Heraklidia A. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:24Z | |
dc.date.available | 2019-11-21T06:19:24Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55560 | |
dc.description.abstract | Asymmetric 3,5-diaryl substituted 4H-1,2,6-thiadiazin-4-ones can be prepared from 3,5-dichloro-4H-1,2,6-thiadiazin-4-one (1) via a multi-step protocol: selective nucleophilic mono-chloro substitution gives either the mono-methoxy or benzyloxy substituted mono-chlorothiadiazinones that can be phenylated via Suzuki-Miyaura coupling. Subsequent BBr 3 mediated dealkylation gives 3-hydroxy-5-phenyl-4H-1,2,6-thiadiazin-4-one (9) that can be activated by a modified Finkelstein halodehydroxylation via the triflate, enabling further arylation reactions using Suzuki-Miyaura or Stille coupling chemistry. © 2012 Elsevier Ltd. All rights reserved. | en |
dc.source | Tetrahedron | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864289770&doi=10.1016%2fj.tet.2012.06.079&partnerID=40&md5=4007e59b615bad7d629258e22fe9cece | |
dc.subject | article | en |
dc.subject | priority journal | en |
dc.subject | unclassified drug | en |
dc.subject | room temperature | en |
dc.subject | arylation | en |
dc.subject | nucleophilicity | en |
dc.subject | asymmetric synthesis | en |
dc.subject | hydrolysis | en |
dc.subject | reaction time | en |
dc.subject | 2 benzyl 5 phenyl 2h 1,2,6 thiadiazine 3,4 dione | en |
dc.subject | 3 (1 methyl 1h pyrrol 2 yl) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (2 methoxyphenyl) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (3 nitrophenyl) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (4 chlorophenyl) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (4 methoxyphenyl) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (benzyloxy) 5 chloro 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (benzyloxy) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 (fur 2 yl) 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 bromo 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 chloro 5 methoxy 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 chloro 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 hydroxy 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 iodo 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 methoxy 5 phenyl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 phenyl 5 (thien 2 yl) 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3 phenyl 5 trifluoromethanesulfonoxy 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | 3,5 diaryl 4h 1,2,6 thiadiazin 4 one | en |
dc.subject | dealkylation | en |
dc.subject | halogenation | en |
dc.subject | hydroxylation | en |
dc.subject | Stille reaction | en |
dc.subject | Suzuki reaction | en |
dc.subject | Suzukie Miyaura reaction | en |
dc.subject | tetracyanoethylene | en |
dc.subject | thiadiazine derivative | en |
dc.subject | trifluoroacetic acid | en |
dc.subject | trifluoromethanesulfonic acid | en |
dc.title | Synthesis of asymmetric 3,5-diaryl-4H-1,2,6-thiadiazin-4-ones via Suzuki-Miyaura and Stille coupling reactions | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.tet.2012.06.079 | |
dc.description.volume | 68 | |
dc.description.issue | 36 | |
dc.description.startingpage | 7380 | |
dc.description.endingpage | 7385 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :5</p> | en |
dc.source.abbreviation | Tetrahedron | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |