dc.contributor.author | Ioannidou, Heraklidia A. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Ioannidou, Heraklidia A. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:24Z | |
dc.date.available | 2019-11-21T06:19:24Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55561 | |
dc.description.abstract | 3,5-Diaryl-4H-1,2,6-thiadiazin-4-ones react with NaBH 4 to give the 3,5-diaryl-4H-1,2,6-thiadiazin-4-ols and with MeLi to give 4-methyl-3,5-diaryl-4H-1,2,6-thiadiazin-4-ols. The latter dehydrate with p-toluenesulfonic acid to give (3,5-diarylthiadiazin-4-ylidene)methanes. (3,5-Diphenyl-4H-1,2,6-thiadiazin-4-ylidene)methane 15 suffers mono bromination with NBS to give bromo(3,5-diphenyl-4H-1,2,6-thiadiazin-4-ylidene)methane 17. Dichloro- and dibromo(3,5-diphenyl-4H-1,2,6-thiadiazin-4-ylidene)methanes 18 and 19 are formed directly from the 3,5-diphenylthiadiazin-4-one 9 via the Appel reaction using Ph 3P and CCl 4 or CBr 4, respectively. 3,5-Diarylthiadiazin-4-ones treated with P 2S 5 give 3,5-diarylthiadiazine-4-thiones that react with tetracyanoethylene oxide to give the (thiadiazin-4-ylidene)malononitriles. Finally, the 3,5-diphenylthiadiazine-4-thione 20 reacts with ethyl diazoacetate to give ethyl 2-(3,5-diphenyl-4H-1,2,6-thiadiazin-4-ylidene)acetate 26. The above reactions show that a variety of substitutions at C-4 of 3,5-diaryl substituted 1,2,6-thiadiazin-4-ones can be achieved, which extends the potential applications of this heterocycle. All compounds are fully characterized and a brief comparison of their spectroscopic properties is given. © 2012 Elsevier Ltd. All rights reserved. | en |
dc.source | Tetrahedron | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857638336&doi=10.1016%2fj.tet.2012.01.098&partnerID=40&md5=bffaaa11a85ca5fd0d0f07ebd9dfdfe3 | |
dc.subject | article | en |
dc.subject | priority journal | en |
dc.subject | unclassified drug | en |
dc.subject | chemical analysis | en |
dc.subject | comparative study | en |
dc.subject | chemical structure | en |
dc.subject | chemical reaction | en |
dc.subject | spectroscopy | en |
dc.subject | tetracyanoethylene | en |
dc.subject | thiadiazine derivative | en |
dc.subject | (3,5 diarylthiadiazin 4 ylidene)methane derivative | en |
dc.subject | (3,5 diphenyl 4h 1,2,6 thiadiazin 4 ylidene)methane | en |
dc.subject | (3,5 dithien 2 yl 4h 1,2,6 thiadiazin 4 ylidene)methane | en |
dc.subject | 2 (3,5 diphenyl 4h 1,2,6 thiadiazin 4 ylidene)malononitrile | en |
dc.subject | 2 (3,5 dithien 2 yl 4h 1,2,6 thiadiazin 4 ylidene)malononitrile | en |
dc.subject | 3,5 diaryl 4h 1,2,6 thiadiazin 4 ol derivative | en |
dc.subject | 3,5 diaryl 4h 1,2,6 thiadiazin 4 one derivative | en |
dc.subject | 3,5 diphenyl 4h 1,2,6 thiadiazine 4 thione | en |
dc.subject | 3,5 dithien 2 yl 4h 1,2,6 thiadiazine 4 thione | en |
dc.subject | 4 methyl 3,5 diaryl 4h 1,2,6 thiadiazin 4 ol derivative | en |
dc.subject | bromination | en |
dc.subject | bromo (3,5 diphenyl 4h 1,2,6 thiadiazin 4 ylidene)methane | en |
dc.subject | dibromo (3,5 diphenyl 4h 1,2,6 thiadiazin 4 ylidene)methane | en |
dc.subject | dichloro (3,5 diphenyl 4h 1,2,6 thiadiazin 4 ylidene)methane | en |
dc.subject | ethyl 2 (3,5 diphenyl 4h 1,2,6 thiadiazin 4 ylidene)acetate | en |
dc.subject | sodium borohydride | en |
dc.title | Substitution at C-4 in 3,5-disubstituted 4H-1,2,6-thiadiazin-4-ones | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.tet.2012.01.098 | |
dc.description.volume | 68 | |
dc.description.issue | 12 | |
dc.description.startingpage | 2590 | |
dc.description.endingpage | 2597 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :11</p> | en |
dc.source.abbreviation | Tetrahedron | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |