Ring transformation of (4-chloro-5H-1,2,3-dithiazol-5-ylidene)acetonitriles to 3-haloisothiazole-5-carbonitriles
Date
2014Author


Ioannidou, Heraklidia A.
Manos, Manolis J.

ISSN
2046-2069Source
RSC AdvancesVolume
4Issue
15Pages
7735-7748Google Scholar check
Keyword(s):
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Ring transformation of readily prepared (4-chloro-5H-1,2,3-dithiazol-5- ylidene)acetonitriles afford 3-haloisothiazole-5-carbonitriles in good to excellent yields. The transformation can be mediated using HBr (g), HCl (g) or BnEt3NCl. Mechanisms for the transformations are discussed, together with rationalizations for the formation of side products. Furthermore, single crystal X-ray structures are provided for (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5- ylidene)acetonitrile and (E)-2-bromo-2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene) acetonitrile confirming the stereochemistry of the exocyclic ethene bond. © 2014 The Royal Society of Chemistry.