dc.contributor.author | Kalogirou, Andreas S. | en |
dc.contributor.author | Manoli, Maria | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Kalogirou, Andreas S. | en |
dc.creator | Manoli, Maria | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:43Z | |
dc.date.available | 2019-11-21T06:19:43Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55630 | |
dc.description.abstract | Tin reduction of 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine afforded perchloro-9-thia-1,5,8,10-tetraazaspiro[5.5]undeca-1,4,7,10-tetraene (10%) and 3,5-dichloro-4H-1,2,6-thiadiazine-4-thione (27%), the structures of which were supported by single crystal X-ray crystallography. Treating the tetrachlorothiadiazine with Ph3P (1 equiv.) afforded the corresponding spirocycle in a useful 66% yield, the degradation of which with BnEt3NCl (0.5 equiv.) afforded densely functionalized 4,5,6-trichloropyrimidine-2-carbonitrile in 81% yield. Rational mechanisms for the formation of products are proposed. © 2017 Elsevier Ltd | en |
dc.source | Tetrahedron letters | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020053164&doi=10.1016%2fj.tetlet.2017.05.082&partnerID=40&md5=a3193208dd857d7c09974a3fbeb3a0a8 | |
dc.subject | Pyrimidine | en |
dc.subject | Ring transformations | en |
dc.subject | Spirocycle | en |
dc.subject | Sulfur-nitrogen heterocycles | en |
dc.subject | Thiophile | en |
dc.title | Two-step conversion of 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine into 4,5,6-trichloropyrimidine-2-carbonitrile | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.tetlet.2017.05.082 | |
dc.description.volume | 58 | |
dc.description.issue | 26 | |
dc.description.startingpage | 2618 | |
dc.description.endingpage | 2621 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | Tetrahedron Lett. | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.contributor.orcid | Kalogirou, Andreas S. [0000-0002-5476-5805] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |
dc.gnosis.orcid | 0000-0002-5476-5805 | |