dc.contributor.author | Kalogirou, Andreas S. | en |
dc.contributor.author | Michaelidou, Sophia S. | en |
dc.contributor.author | White, A. J. P. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Kalogirou, Andreas S. | en |
dc.creator | Michaelidou, Sophia S. | en |
dc.creator | White, A. J. P. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:44Z | |
dc.date.available | 2019-11-21T06:19:44Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55635 | |
dc.description.abstract | The reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile (14) with a range of primary and secondary amines are investigated. Treatment with n-BuNH2 and BnNH2 gave 1,3-di-n-butyl- and 1,3-dibenzyl-2-(3,5-dicyano-6-ethoxy-4-phenylpyrid-2-yl)guanidines 15a (32%) and 15b (82%), respectively. While treatment with Et2NH, n-Pr2NH or Bn2NH gave the analogous 4-dialkylaminopyrido[2,3-d]pyrimidines 16c-e in high yields. Treatment of the dithiazole 14 with pyrrolidine, piperidine or morpholine gave the analogous 4-dialkylaminopyrido[2,3-d]pyrimidines 16f-h, the 2-aminopyridine 13 and 2-(diamino-1-ylmethyleneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitriles 15f-h. The 4-dialkylaminopyrido[2,3-d]pyrimidines 16f-h are converted to the 2-(dialkylamino-1-ylmethyleneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitriles 15f-h upon further reaction with excess dialkylamines. The structure and origins of the two side products 17 and 18 are also discussed. Tentative mechanisms for these transformations are proposed. © 2015 Elsevier Ltd. All rights reserved. | en |
dc.source | Tetrahedron | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923542363&doi=10.1016%2fj.tet.2015.02.006&partnerID=40&md5=3c45320a5e628ea53618d5a27c3dfda0 | |
dc.subject | priority journal | en |
dc.subject | unclassified drug | en |
dc.subject | Article | en |
dc.subject | Pyrimidines | en |
dc.subject | drug synthesis | en |
dc.subject | stereospecificity | en |
dc.subject | Pyridines | en |
dc.subject | drug structure | en |
dc.subject | guanidine derivative | en |
dc.subject | Guanidines | en |
dc.subject | nucleophilicity | en |
dc.subject | hydrolysis | en |
dc.subject | ring opening | en |
dc.subject | reaction time | en |
dc.subject | Ring transformations | en |
dc.subject | Sulfur-nitrogen heterocycles | en |
dc.subject | 1,3 di n butyl 2 (3,5 dicyano 6 ethoxy 4 phenylpyridin 2 yl)guanidine | en |
dc.subject | 1,3 dibenzyl 2 (3,5 dicyano 6 ethoxy 4 phenylpyridin 2 yl)guanidine | en |
dc.subject | 2 [4 (diethylamino) 5h 1,2,3 dithiazol 5 ylideneamino] 6 ethoxy 4 phenylpyridine 3,5 dicarbonitrile | en |
dc.subject | 4 (di n propylamino) 7 ethoxy 5 phenylpyrido[2,3 d]pyrimidine 2,6 dicarbonitrile | en |
dc.subject | 4 (dibenzylamino) 7 ethoxy 5 phenylpyrido[2,3 d]pyrimidine 2,6 dicarbonitrile | en |
dc.subject | 4 (diethylamino) 7 ethoxy 5 phenylpyrido[2,3 d]pyrimidine 2,6 dicarbonitrile | en |
dc.subject | 6,6' [[4,4' bis(diethylamino) 5h,5'h (2,20 bithiazolylidene) 5,5' diylidene]bis(azanylylidene)] bis (2 ethoxy 4 phenylpyridine 3,5 dicarbonitrile) | en |
dc.subject | 7 ethoxy 5 phenyl 4 (morpholin 4 yl)pyrido[2,3 d]pyrimidine 2,6 dicarbonitrile | en |
dc.subject | 7 ethoxy 5 phenyl 4 (piperidin 1 yl)pyrido[2,3 d]pyrimidine 2,6 dicarbonitrile | en |
dc.subject | 7 ethoxy 5 phenyl 4 (pyrrolidin 1 yl)pyrido[2,3 d]pyrimidine 2,6 dicarbonitrile | en |
dc.subject | drug transformation | en |
dc.subject | KFused heterocycles | en |
dc.subject | pyrido[2,3 d]pyrimidine derivative | en |
dc.title | Transformation of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile into 4-aminopyrido[2,3-d]pyrimidines and 2-(pyrid-2-yl)guanidines | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.tet.2015.02.006 | |
dc.description.volume | 71 | |
dc.description.issue | 12 | |
dc.description.startingpage | 1799 | |
dc.description.endingpage | 1807 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :3</p> | en |
dc.source.abbreviation | Tetrahedron | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.contributor.orcid | Kalogirou, Andreas S. [0000-0002-5476-5805] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |
dc.gnosis.orcid | 0000-0002-5476-5805 | |