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dc.contributor.authorKeramidas, Anastasios D.en
dc.contributor.authorMaltezou, E.en
dc.contributor.authorStylianou, Mariosen
dc.contributor.authorRoy, S.en
dc.contributor.authorDrouza, Chryssoulaen
dc.creatorKeramidas, Anastasios D.en
dc.creatorMaltezou, E.en
dc.creatorStylianou, Mariosen
dc.creatorRoy, S.en
dc.creatorDrouza, Chryssoulaen
dc.description.abstractBisphosphonates are biologically relevant therapeutics for bone disorders and cancer. Reaction of γ-chlorobutyric acid, phosphorus acid, and phosphorus trichloride without the use of solvent gave the tetrahydrofuranyl-2, 2-bisphosphonate sodium salt (Na2H2L). The Na 2H2L was isolated, characterized in solution by 1H, 13C, and 31P NMR spectroscopy and in solid state by single X-Ray crystallography. The crystal structure showed that the Na2H2L forms in the crystal infinite two-dimensional sheets stacked one parallel to the other. A comparison of the chelating properties of H2L2- with similar hydroxyl bisphosphonate ligands shows that the strength of the NaO(furanyl/hydroxyl) bond is directly related to the total charge of the ligand anion. Copyright © 2010 Elena Maltezou et al.en
dc.sourceBioinorganic Chemistry and Applicationsen
dc.titleSynthesis, solution, and structural characterization of tetrahydrofuranyl-2,2-bisphosphonic acid disodium salten
dc.description.volume2010 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied SciencesΤμήμα Χημείας / Department of Chemistry
dc.description.notes<p>Cited By :2</p>en
dc.contributor.orcidKeramidas, Anastasios D. [0000-0002-0446-8220]
dc.contributor.orcidDrouza, Chryssoula [0000-0002-2630-4323]

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