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dc.contributor.authorKoutentis, Panayiotis Andreasen
dc.contributor.authorKrassos, H.en
dc.contributor.authorLo Re, D.en
dc.creatorKoutentis, Panayiotis Andreasen
dc.creatorKrassos, H.en
dc.creatorLo Re, D.en
dc.date.accessioned2019-11-21T06:20:32Z
dc.date.available2019-11-21T06:20:32Z
dc.date.issued2011
dc.identifier.issn1477-0520
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55725
dc.description.abstract1,3-Diphenylbenzo[e][1,2,4]triazin-7(1H)-one (6) reacts with tetracyanoethylene (TCNE) or tetracyanoethylene oxide (TCNEO) to give the deep green 2-[1,3-diphenylbenzo[e][1,2,4]triazin-7(1H)-ylidene]propanedinitrile (11) in 17 and 15% yields, respectively. Nucleophiles such as amines, alkoxides, thiols and Grignard reagents all reacted with the 1,3-diphenylbenzotriazinone 6 regioselectively at C-6, while halogenating agents reacted exclusively at C-8. Furthermore, 8-iodo-1,3-diphenylbenzo[e][1,2,4]triazin-7(1H)-one (32) undergoes palladium-catalysed Suzuki-Miyaura and Stille coupling reactions to give 8-aryl- or heteroaryl-substituted benzotriazinones. By combining both the C-6 and C-8 chemistries 1,3,6,8-tetraphenylbenzo[e][1,2,4]triazin-7(1H)-one (42) and 1,3-diphenyl-6,8-di(thien-2-yl)-benzo[e][1,2,4]triazin-7(1H)-one (43) can be prepared. All new compounds are fully characterized. © The Royal Society of Chemistry 2011.en
dc.sourceOrganic and Biomolecular Chemistryen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79959784308&doi=10.1039%2fc1ob05410d&partnerID=40&md5=1411317c28d6954fbb3363e00a05f19e
dc.subjectChemical reactionsen
dc.subjectPalladiumen
dc.subjectChemical bondsen
dc.subjectHuman echovirus 1en
dc.subjectAlkoxidesen
dc.subjectGrignard reagenten
dc.subjectNucleophilesen
dc.subjectPropanedinitrileen
dc.subjectStille coupling reactionen
dc.subjectSuzuki-Miyauraen
dc.subjectTetracyanoethyleneen
dc.title1,3-diphenylbenzo[e][1,2,4]triazin-7(1H)-one: Selected chemistry at the C-6, C-7 and C-8 positionsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1039/c1ob05410d
dc.description.volume9
dc.description.issue14
dc.description.startingpage5228
dc.description.endingpage5237
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :11</p>en
dc.source.abbreviationOrg.Biomol.Chem.en
dc.contributor.orcidKoutentis, Panayiotis Andreas [0000-0002-4652-7567]
dc.gnosis.orcid0000-0002-4652-7567


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