dc.contributor.author | Koyioni, Maria G. | en |
dc.contributor.author | Manoli, Maria | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Koyioni, Maria G. | en |
dc.creator | Manoli, Maria | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:20:57Z | |
dc.date.available | 2019-11-21T06:20:57Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55743 | |
dc.description.abstract | N-(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)anilines react with DABCO in hot PhCl to give N-{4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene}anilines in high yields (70-92%). The reaction also works with 4-chloro-5H-1,2,3-dithiazol-5-one and -thione, giving the corresponding products in 85% and 76% yields, respectively. While the reaction of several (4-chloro-5H-1,2,3-dithiazol-5-ylidene)methanes with DABCO failed to give {4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene}methanes, these can be prepared in moderate yields via classical cycloaddition-retrocycloaddition strategies from 4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazole-5-thione. The 2-chloroethyl moiety on selected dithiazoles was also modified without cleavage of the 1,2,3-dithiazole by reaction with various nucleophiles, giving access to 4-[N-(2-substituted)piperazin-1-yl]-5H-1,2,3-dithiazoles in moderate to high yields. © 2015 American Chemical Society. | en |
dc.source | Journal of Organic Chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955143621&doi=10.1021%2facs.joc.5b02497&partnerID=40&md5=26d606a5b06d2c748782a4fcf8f52272 | |
dc.subject | unclassified drug | en |
dc.subject | Article | en |
dc.subject | aniline derivative | en |
dc.subject | High yield | en |
dc.subject | pyrrole derivative | en |
dc.subject | cyclization | en |
dc.subject | nucleophilicity | en |
dc.subject | cycloaddition | en |
dc.subject | thiol derivative | en |
dc.subject | Methane | en |
dc.subject | nucleophile | en |
dc.subject | electrophilicity | en |
dc.subject | 1,4 diazabicyclo[2.2.2]octane | en |
dc.subject | 4 [n (2 chloroethyl)piperazin 1 yl] 5h 1,2,3 dithiazole derivative | en |
dc.subject | Aniline | en |
dc.subject | Retrocycloaddition | en |
dc.title | The Reaction of DABCO with 4-Chloro-5H-1,2,3-dithiazoles: Synthesis and Chemistry of 4-[N-(2-Chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazoles | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1021/acs.joc.5b02497 | |
dc.description.volume | 81 | |
dc.description.issue | 2 | |
dc.description.startingpage | 615 | |
dc.description.endingpage | 631 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :3</p> | en |
dc.source.abbreviation | J.Org.Chem. | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.contributor.orcid | Koyioni, Maria [0000-0002-2786-7523] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |
dc.gnosis.orcid | 0000-0002-2786-7523 | |