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Cationic star polymer siRNA transfectants interconnected with a piperazine-based cationic cross-linker

dc.contributor.authorPafiti, Kyriaki S.en
dc.contributor.authorPatrickios, Costas S.en
dc.contributor.authorGeorgiou, Theoni K.en
dc.contributor.authorYamasaki, E. N.en
dc.contributor.authorMastroyiannopoulos, Nikolaos P.en
dc.contributor.authorPhylactou, Leonidas A.en
dc.creatorPafiti, Kyriaki S.en
dc.creatorPatrickios, Costas S.en
dc.creatorGeorgiou, Theoni K.en
dc.creatorYamasaki, E. N.en
dc.creatorMastroyiannopoulos, Nikolaos P.en
dc.creatorPhylactou, Leonidas A.en
dc.date.accessioned2019-11-21T06:21:55Z
dc.date.available2019-11-21T06:21:55Z
dc.date.issued2012
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55943
dc.description.abstractCationic star polymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) were prepared via the "arm-first" method under group transfer polymerization (GTP) conditions, and were interconnected using a novel, hydrophilic, positively ionizable dimethacrylate cross-linker which is essentially the cyclic dimer of DMAEMA, thus ensuring that the building units of the arms and the core of the star polymers were identical. After their physicochemical characterization, these star-like polyamines were evaluated for their ability to transfer small interfering RNA (siRNA) to murine myoblast cells. Suppression efficiency was found to increase with polymer loading and star branch size, attaining sufficiently high values, comparable to that observed with standard non-viral siRNA transfection systems, while cytotoxicity was kept reasonably low. © 2012 Elsevier Ltd. All rights reserved.en
dc.sourceEuropean Polymer Journalen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84863989425&doi=10.1016%2fj.eurpolymj.2012.05.008&partnerID=40&md5=63e91d53fb75f52513df95beb49e255c
dc.subjectRNAen
dc.subjectPolymersen
dc.subjectLoadingen
dc.subjectStarsen
dc.subjectCrosslinkingen
dc.subjectPolymerizationen
dc.subjectGene transferen
dc.subjectGroup transfer polymerizationen
dc.subjectCrosslinkeren
dc.subjectStar polymersen
dc.subjectDimersen
dc.subjectPiperazine cross-linkeren
dc.subjectsiRNA deliveryen
dc.subjectsiRNA delivery systemsen
dc.subjectSmall interfering RNAen
dc.titleCationic star polymer siRNA transfectants interconnected with a piperazine-based cationic cross-linkeren
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.eurpolymj.2012.05.008
dc.description.volume48
dc.description.issue8
dc.description.startingpage1422
dc.description.endingpage1430
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :15</p>en
dc.source.abbreviationEur Polym Jen
dc.contributor.orcidPatrickios, Costas S. [0000-0001-8855-0370]
dc.contributor.orcidGeorgiou, Theoni K. [0000-0003-4474-6931]
dc.gnosis.orcid0000-0001-8855-0370
dc.gnosis.orcid0000-0003-4474-6931


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