dc.contributor.author | Rizeq, N. | en |
dc.contributor.author | Georgiades, Savvas N. | en |
dc.creator | Rizeq, N. | en |
dc.creator | Georgiades, Savvas N. | en |
dc.date.accessioned | 2019-11-21T06:22:38Z | |
dc.date.available | 2019-11-21T06:22:38Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1434-193X | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/56089 | |
dc.description.abstract | Five unprecedented pyridyl-oxazole oligomers exhibiting either linear or branched connectivity of their subunits were developed as a family of potential G-quadruplex-interacting ligands. Our synthesis employed variations of a key Pd/Cu-mediated C-C cross-coupling/C-H activation reaction to gain access to the oligomer products from a small set of substituted pyridine building blocks. The effect of the compounds on the conformation of a c-myc oncogene promoter G-quadruplex was investigated by circular dichroism under various conditions. Some or all of the compounds induced detectable helicity enhancement in low-cation and Na+-rich Tris-HCl (pH 7.4) buffers, respectively, in which the helix was only partially prefolded. Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | en |
dc.source | European Journal of Organic Chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954520826&doi=10.1002%2fejoc.201501269&partnerID=40&md5=16abcd4d49318cb1550cb7adbacb21c0 | |
dc.subject | DNA | en |
dc.subject | N,O ligands | en |
dc.subject | Nitrogen heterocycles | en |
dc.subject | C-H activation | en |
dc.subject | G-Quadruplexes | en |
dc.title | Linear and Branched Pyridyl-Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c-Myc G-Quadruplex Helicity | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/ejoc.201501269 | |
dc.description.volume | 2016 | |
dc.description.issue | 1 | |
dc.description.startingpage | 122 | |
dc.description.endingpage | 131 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :1</p> | en |
dc.source.abbreviation | Eur.J.Org.Chem. | en |
dc.contributor.orcid | Georgiades, Savvas N. [0000-0002-6106-9904] | |
dc.gnosis.orcid | 0000-0002-6106-9904 | |