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dc.contributor.authorRizeq, Nataliaen
dc.contributor.authorGeorgiades, Savvas N.en
dc.creatorRizeq, Nataliaen
dc.creatorGeorgiades, Savvas N.en
dc.subjectOrganic compoundsen
dc.subjectChemistry, Organicen
dc.subjectBioorganic chemistryen
dc.subjectChemistry, Physical organicen
dc.titleLinear and Branched Pyridyl–Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c‐Myc G‐Quadruplex Helicityen
dc.typeinfo:eu-repo/semantics/article Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied SciencesΤμήμα Χημείας / Department of Chemistry
dc.description.notes<p>ID: 1049en
dc.description.notesIn: European journal of organic chemistry, Vol. 2016, no. 1 ( 2016), p.122-131.en
dc.description.notesSummary: AbstractFive unprecedented pyridyl–oxazole oligomers exhibiting either linear or branched connectivity of their subunits were developed as a family of potential G‐quadruplex‐interacting ligands. Our synthesis employed variations of a key Pd/Cu‐mediated C–C cross‐coupling/C–H activation reaction to gain access to the oligomer products from a small set of substituted pyridine building blocks. The effect of the compounds on the conformation of a c‐myc oncogene promoter G‐quadruplex was investigated by circular dichroism under various conditions. Some or all of the compounds induced detectable helicity enhancement in low‐cation and Na+‐rich Tris‐HCl (pH 7.4) buffers, respectively, in which the helix was only partially prefolded.AbstractA family of pyridyl–oxazole oligomers with either linear or branched connectivity of their subunits is synthesized. According to circular dichroism spectroscopy, some of the members of this family enhance the helicity of a partially folded c‐myc G‐quadruplex.</p>en
dc.contributor.orcidGeorgiades, Savvas N. [0000-0002-6106-9904]

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