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dc.contributor.authorStefan-Van Staden, R. -Ien
dc.contributor.authorMitrofan, Grigorinaen
dc.contributor.authorComnea‐Stancu, Ionela Ralucaen
dc.contributor.authorVan Staden, J. F.en
dc.contributor.authorKapnissi‐Christodoulou, Constantina P.en
dc.contributor.authorAboul‐Enein, Hassan Y.en
dc.creatorStefan-Van Staden, R. -Ien
dc.creatorMitrofan, Grigorinaen
dc.creatorComnea‐Stancu, Ionela Ralucaen
dc.creatorVan Staden, J. F.en
dc.creatorKapnissi‐Christodoulou, Constantina P.en
dc.creatorAboul‐Enein, Hassan Y.en
dc.date.accessioned2019-11-21T06:22:59Z
dc.date.available2019-11-21T06:22:59Z
dc.date.issued2015
dc.identifier.issn2046-2069
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/56165
dc.description.abstractIonic liquids were proposed for the molecular enantiorecognition of free l-T3, l-T4 and d-T4. l-Phenylalanine tert-butyl ester lactate (l-PheC4-Lac), l-alanine tert-butyl ester l-lactate (l-AlaC4-Lac) and l-alanine tert-butyl ester nitrate (l-AlaC4-NO3) were physically immobilized in a diamond paste. The best linear concentration range for the assay of free l-T4 was obtained with the microsensor modified with l-AlaC4-NO3 (1 × 10-10-1 × 10-8 mol L-1) while for the assay of free l-T3 and free d-T4, the microsensor based on l-PheC4-Lac provided the best linear ranges of 6 × 10-12-1 × 10-11 mol L-1, and 1 × 10-11-1 × 10-9 mol L-1, respectively. The signature of the analytes (the toff value) was different for each sensor, proving their enantiorecognition capacity. The main advantages of the constructed sensors are that the limits of determination achieved for free l-T3 (6 × 10-12 mol L-1), free l-T4 (1 × 10-6 mol L-1) and free d-T4 (1 × 10-11 mol L-1) are low, the sample did not need any pretreatment before measurement, the assay is fast and reliable, and can be performed for both whole blood or pharmaceutical formulations without any sample pretreatment steps for whole blood samples, and by just dissolving the T4 tablets in distilled water. The recoveries were higher than 99.00% for all thyroid hormones with RSD (%) values lower than 1.00%. © The Royal Society of Chemistry.en
dc.sourceRSC Advancesen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84941254086&doi=10.1039%2fc5ra14635f&partnerID=40&md5=1f48a3167671a2d366a1e3ff04bc25aa
dc.subjectBlooden
dc.subjectEstersen
dc.subjectIonic liquidsen
dc.subjectHormonesen
dc.subjectAmino acidsen
dc.subjectLinear concentrationen
dc.subjectMicrosensorsen
dc.subjectPharmaceutical formulationen
dc.subjectDiamond pastesen
dc.subjectDistilled wateren
dc.subjectl-Phenylalanineen
dc.subjectSample pretreatmenten
dc.subjectTert-butyl estersen
dc.subjectThyroid hormonesen
dc.titleIonic liquids for the molecular enantiorecognition of free l-T3, l-T4 and d-T4en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1039/c5ra14635f
dc.description.volume5
dc.description.issue92
dc.description.startingpage75451
dc.description.endingpage75457
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :1</p>en
dc.source.abbreviationRSC Adv.en
dc.contributor.orcidKapnissi‐Christodoulou, Constantina P. [0000-0003-3755-1052]
dc.gnosis.orcid0000-0003-3755-1052


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