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dc.contributor.authorKeane, Lee-Ann J.en
dc.contributor.authorMirallai, Styliana I.en
dc.contributor.authorSweeney, Martinen
dc.contributor.authorCarty, Michael P.en
dc.contributor.authorZissimou, Georgia A.en
dc.contributor.authorBerezin, Andrey A.en
dc.contributor.authorKoutentis, Panayiotis A.en
dc.contributor.authorAldabbagh, Fawazen
dc.creatorKeane, Lee-Ann J.en
dc.creatorMirallai, Styliana I.en
dc.creatorSweeney, Martinen
dc.creatorCarty, Michael P.en
dc.creatorZissimou, Georgia A.en
dc.creatorBerezin, Andrey A.en
dc.creatorKoutentis, Panayiotis A.en
dc.creatorAldabbagh, Fawazen
dc.date.accessioned2021-01-25T09:44:46Z
dc.date.available2021-01-25T09:44:46Z
dc.date.issued2018
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/63021
dc.description.abstractCell viability studies for benzo[1,2,4]triazin-7-ones and 1,2,4-benzotriazinyl (Blatter-type) radical precursors are described with comparisons made with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). All of the stable free radicals were several orders of magnitude less cytotoxic than the benzo[1,2,4]triazin-7-ones. The synthesis and evaluation of two new pyrid-2-yl benzo[1,2,4]triazin-7-ones are described, where altering the 1,3-substitution from phenyl to pyrid-2-yl increased cytotoxicity against most cancer cell lines, as indicated using National Cancer Institute (NCI) one-dose testing. COMPARE analysis of five-dose testing data from the NCI showed very strong correlations to the naturally occurring anti-cancer compound pleurotin. COMPARE is program, which analyzes similarities in cytotoxicity data of compounds, and enables quantitative expression as Pearson correlation coefficients. Compounds were also evaluated using the independent MTT assay, which was compared with SRB assay data generated at the NCI.en
dc.language.isoenen
dc.sourceMoleculesen
dc.source.urihttps://www.mdpi.com/1420-3049/23/3/574
dc.titleAnti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursorsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/molecules23030574
dc.description.volume23
dc.description.issue3
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.contributor.orcidZissimou, Georgia A. [0000-0003-4821-9469]
dc.contributor.orcidMirallai, Styliana I. [0000-0002-8195-8741]
dc.contributor.orcidKoutentis, Panayiotis A. [0000-0002-4652-7567]
dc.gnosis.orcid0000-0003-4821-9469
dc.gnosis.orcid0000-0002-8195-8741
dc.gnosis.orcid0000-0002-4652-7567


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