dc.contributor.author | Asquith, Christopher R. M. | en |
dc.contributor.author | Godoi, Paulo H. | en |
dc.contributor.author | Couñago, Rafael M. | en |
dc.contributor.author | Laitinen, Tuomo | en |
dc.contributor.author | Scott, John W. | en |
dc.contributor.author | Langendorf, Christopher G. | en |
dc.contributor.author | Oakhill, Jonathan S. | en |
dc.contributor.author | Drewry, David H. | en |
dc.contributor.author | Zuercher, William J. | en |
dc.contributor.author | Koutentis, Panayiotis A. | en |
dc.contributor.author | Willson, Timothy M. | en |
dc.contributor.author | Kalogirou, Andreas S. | en |
dc.creator | Asquith, Christopher R. M. | en |
dc.creator | Godoi, Paulo H. | en |
dc.creator | Couñago, Rafael M. | en |
dc.creator | Laitinen, Tuomo | en |
dc.creator | Scott, John W. | en |
dc.creator | Langendorf, Christopher G. | en |
dc.creator | Oakhill, Jonathan S. | en |
dc.creator | Drewry, David H. | en |
dc.creator | Zuercher, William J. | en |
dc.creator | Koutentis, Panayiotis A. | en |
dc.creator | Willson, Timothy M. | en |
dc.creator | Kalogirou, Andreas S. | en |
dc.date.accessioned | 2021-01-25T09:44:47Z | |
dc.date.available | 2021-01-25T09:44:47Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/63024 | |
dc.description.abstract | We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), several analogues were identified with micromolar activity through targeted displacement of bound water molecules in the active site. Since the TDZ analogues showed reduced promiscuity compared to their 2,4-dianilinopyrimidine counter parts, they represent starting points for development of highly selective kinase inhibitors. | en |
dc.language.iso | en | en |
dc.source | Molecules | en |
dc.source.uri | https://www.mdpi.com/1420-3049/23/5/1221 | |
dc.title | 1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.3390/molecules23051221 | |
dc.description.volume | 23 | |
dc.description.issue | 5 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Kalogirou, Andreas S. [0000-0002-5476-5805] | |
dc.contributor.orcid | Koutentis, Panayiotis A. [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-5476-5805 | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |