| dc.contributor.author | Kalogirou, Andreas S. | en |
| dc.contributor.author | Koutentis, Panayiotis A. | en |
| dc.creator | Kalogirou, Andreas S. | en |
| dc.creator | Koutentis, Panayiotis A. | en |
| dc.date.accessioned | 2021-01-25T09:44:47Z | |
| dc.date.available | 2021-01-25T09:44:47Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/63031 | |
| dc.description.abstract | 4,6-Dichloro-2-(methylthio)pyrimidine (7) was converted to 4-chloro-6-methoxy-2-(methylthio)pyrimidine (15) and 4,6-dimethoxy-2-(methylthio)pyrimidine (14). Chlorination of the latter with N-chlorosuccinimide (NCS) affords 5-chloro-4,6-dimethoxy-2-(methylthio)pyrimidine (16) in 56% yield. Both methylthiopyrimidines 15 and 14 were converted in two steps to 4-chloro-6-methoxypyrimidine-2-carbonitrile (13) and 4,6-dimethoxypyrimidine-2-carbonitrile (12), respectively, after oxidation to sulfones and displacement of the sulfinate group with KCN. 4,6-Dimethoxypyrimidine-2-carbonitrile (12) was chlorinated with NCS to give 5-chloro-4,6-dimethoxypyrimidine-2-carbonitrile (10) in 53% yield. All new compounds were fully characterized. | en |
| dc.language.iso | en | en |
| dc.source | Molbank | en |
| dc.source.uri | https://www.mdpi.com/1422-8599/2019/4/M1086 | |
| dc.title | Synthesis of 2-Cyanopyrimidines | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | 10.3390/M1086 | |
| dc.description.volume | 2019 | |
| dc.description.issue | 4 | |
| dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
| dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
| dc.type.uhtype | Article | en |
| dc.contributor.orcid | Kalogirou, Andreas S. [0000-0002-5476-5805] | |
| dc.contributor.orcid | Koutentis, Panayiotis A. [0000-0002-4652-7567] | |
| dc.gnosis.orcid | 0000-0002-5476-5805 | |
| dc.gnosis.orcid | 0000-0002-4652-7567 | |
