dc.contributor.author | Mirallai, Styliana I. | en |
dc.contributor.author | Koutentis, Panayiotis A. | en |
dc.contributor.author | Aldabbagh, Fawaz | en |
dc.creator | Mirallai, Styliana I. | en |
dc.creator | Koutentis, Panayiotis A. | en |
dc.creator | Aldabbagh, Fawaz | en |
dc.date.accessioned | 2021-01-25T09:44:48Z | |
dc.date.available | 2021-01-25T09:44:48Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/63037 | |
dc.description.abstract | 7-Oxo-1,2,4-benzotriazines (benzo[1,2,4]triazin-7-ones) are reversible thioredoxin reductase inhibitors that exhibit very strong correlations to pleurotin. In this article, we provide the first synthesis of fluorinated derivatives. Fluorination using Selectfluor of benzo[1,2,4]triazin-7-ones occurs regioselectively and in high yield at the enamine-activated position. This electron N-lone pair activation overrides the activation/deactivation effects of some other substituents. The reaction time was significantly reduced with the use of microwave irradiation at 120 ° | en |
dc.description.abstract | C and 7 bar. The cytotoxicity and cyclic voltammetry measurements for 8-fluoro-1,3-diphenylbenzo[e][1,2,4]triazin-7(1H)-one (2) are presented and compared with its synthetic precursor, 1,3-diphenylbenzo[e][1,2,4]triazin-7(1H)-one (1a). | en |
dc.language.iso | en | en |
dc.source | Molecules | en |
dc.source.uri | https://www.mdpi.com/1420-3049/24/2/282 | |
dc.title | Regioselective Fluorination of 7-Oxo-1,2,4-benzotriazines Using Selectfluor | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.3390/molecules24020282 | |
dc.description.volume | 24 | |
dc.description.issue | 2 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Mirallai, Styliana I. [0000-0002-8195-8741] | |
dc.contributor.orcid | Koutentis, Panayiotis A. [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-8195-8741 | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |