dc.contributor.author | Banti, C. N. | en |
dc.contributor.author | Tsiatouras, V. | en |
dc.contributor.author | Karanicolas, K. | en |
dc.contributor.author | Panagiotou, N. | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Kourkoumelis, N. | en |
dc.contributor.author | Hadjikakou, S. K. | en |
dc.creator | Banti, C. N. | en |
dc.creator | Tsiatouras, V. | en |
dc.creator | Karanicolas, K. | en |
dc.creator | Panagiotou, N. | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Kourkoumelis, N. | en |
dc.creator | Hadjikakou, S. K. | en |
dc.date.accessioned | 2021-01-25T09:44:59Z | |
dc.date.available | 2021-01-25T09:44:59Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1573-501X | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/63126 | |
dc.description.abstract | Three known organo-antimony(III)–copper(I), mixed-metal small bioactive molecules (SBAMs) of formula [Cu(tpSb)3Cl] (1), [Cu2(tpSb)4Br2] (2) and [Cu2(tpSb)4I2] (3) (tpSb = triphenylstibine) were used for the clarification of their antiproliferative activity against human breast cancer cells: MCF-7 (hormone-dependent cells) and MDA-MB-231 (hormone-independent cells). The in vitro toxicity of 1–3 was studied against normal human foetal lung fibroblast cells (MRC-5). The genotoxicity of 1–3 was determined by the presence of micronucleus. The type of the cell death caused by 1–3 was determined using cell cycle arrest. The molecular mechanism of action of 1–3 was defined by their binding affinity towards CT-DNA (calf thymus DNA) using UV spectroscopy and viscosity measurements. Docking studies depict the interactions between 1–3 and DNA. Computations were also employed in order to rationalize the activity of these compounds. This is based on the contribution of metal aromaticity in the case of compounds 2 and 3 where the short Cu···Cu distance (2.7724(6) (2) and 2.7251(11) (3) Ǻ, respectively) suggests d10–d10 interaction between metal centres. | en |
dc.language.iso | en | en |
dc.source | Molecular Diversity | en |
dc.source.uri | https://doi.org/10.1007/s11030-019-10014-z | |
dc.title | Antiproliferative activity and apoptosis induction, of organo-antimony(III)–copper(I) conjugates, against human breast cancer cells | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s11030-019-10014-z | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | Mol Divers | en |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Kourkoumelis, N. [0000-0003-3264-2406] | |
dc.contributor.orcid | Banti, C. N. [0000-0001-6727-2711] | |
dc.contributor.orcid | Hadjikakou, S. K. [0000-0001-9556-6266] | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0003-3264-2406 | |
dc.gnosis.orcid | 0000-0001-6727-2711 | |
dc.gnosis.orcid | 0000-0001-9556-6266 | |