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dc.contributor.authorAriane, Mostaphaen
dc.contributor.authorKassinos, Stavrosen
dc.contributor.authorVelaga, Sitaramen
dc.contributor.authorAlexiadis, Alessioen
dc.creatorAriane, Mostaphaen
dc.creatorKassinos, Stavrosen
dc.creatorVelaga, Sitaramen
dc.creatorAlexiadis, Alessioen
dc.description.abstractIn this paper, the mass transfer coefficient (permeability) of boundary layers containing motile cilia is investigated by means of discrete multi-physics. The idea is to understand the main mechanisms of mass transport occurring in a ciliated-layeren
dc.description.abstractone specific application being inhaled drugs in the respiratory epithelium. The effect of drug diffusivity, cilia beat frequency and cilia flexibility is studied. Our results show the existence of three mass transfer regimes. A low frequency regime, which we called shielding regime, where the presence of the cilia hinders mass transporten
dc.description.abstractan intermediate frequency regime, which we have called diffusive regime, where diffusion is the controlling mechanismen
dc.description.abstractand a high frequency regime, which we have called convective regime, where the degree of bending of the cilia seems to be the most important factor controlling mass transfer in the ciliated-layer. Since the flexibility of the cilia and the frequency of the beat changes with age and health conditions, the knowledge of these three regimes allows prediction of how mass transfer varies with these factors.en
dc.sourceComputers in Biology and Medicineen
dc.titleDiscrete multi-physics simulations of diffusive and convective mass transfer in boundary layers containing motile cilia in lungsen
dc.description.endingpage42Πολυτεχνική Σχολή / Faculty of EngineeringΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.source.abbreviationComputers in Biology and Medicineen
dc.contributor.orcidKassinos, Stavros [0000-0002-3501-3851]

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