dc.contributor.author | Stylianou, Andreas | en |
dc.contributor.author | Lekka, Malgorzata | en |
dc.contributor.author | Stylianopoulos, Triantafyllos | en |
dc.creator | Stylianou, Andreas | en |
dc.creator | Lekka, Malgorzata | en |
dc.creator | Stylianopoulos, Triantafyllos | en |
dc.date.accessioned | 2021-01-27T10:17:46Z | |
dc.date.available | 2021-01-27T10:17:46Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2040-3372 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/63787 | |
dc.description.abstract | Cancer development and progression are closely associated with changes both in the mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix (ECM) structure, composition, and mechanics. In this paper, we review the use of atomic force microscopy (AFM) as a tool for assessing the nanomechanical fingerprints of solid tumors, so as to be potentially used as a diagnostic biomarker for more accurate identification and early cancer grading/classification. The development of such a methodology is expected to provide new insights and a novel approach for cancer diagnosis. We propose that AFM measurements could be employed to complement standard biopsy procedures, offering an objective, novel and quantitative diagnostic approach with the properties of a blind assay, allowing unbiased evaluation of the sample. | en |
dc.language.iso | eng | en |
dc.source | Nanoscale | en |
dc.source.uri | http://www.ncbi.nlm.nih.gov/pubmed/30406223 | |
dc.title | AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1039/c8nr06146g | |
dc.description.volume | 10 | |
dc.description.issue | 45 | |
dc.description.startingpage | 20930 | |
dc.description.endingpage | 20945 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | Nanoscale | en |
dc.contributor.orcid | Stylianopoulos, Triantafyllos [0000-0002-3093-1696] | |
dc.gnosis.orcid | 0000-0002-3093-1696 | |