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dc.contributor.authorKalli, Mariaen
dc.contributor.authorMinia, Angelikien
dc.contributor.authorPliaka, Vaiaen
dc.contributor.authorFotis, Christosen
dc.contributor.authorAlexopoulos, Leonidas G.en
dc.contributor.authorStylianopoulos, Triantafyllosen
dc.creatorKalli, Mariaen
dc.creatorMinia, Angelikien
dc.creatorPliaka, Vaiaen
dc.creatorFotis, Christosen
dc.creatorAlexopoulos, Leonidas G.en
dc.creatorStylianopoulos, Triantafyllosen
dc.description.abstractSolid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms of how it is implicated in cancer metastasis is not yet fully understood. Here, we used two pancreatic cancer cell lines and an established in vitro system to study the effect of solid stress-induced signal transduction on pancreatic cancer cell migration as well as the mechanism involved. Our results show that the migratory ability of cells increases as a direct response to solid stress. We also found that Growth Differentiation Factor 15 (GDF15) expression and secretion is strongly upregulated in pancreatic cancer cells in response to mechanical compression. Performing a phosphoprotein screening, we identified that solid stress activates the Akt/CREB1 pathway to transcriptionally regulate GDF15 expression, which eventually promotes pancreatic cancer cell migration. Our results suggest a novel solid stress signal transduction mechanism bringing GDF15 to the centre of pancreatic tumor biology and rendering it a potential target for future anti-metastatic therapeutic innovations.en
dc.sourceScientific Reportsen
dc.titleSolid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cellsen
dc.description.issue1Πολυτεχνική Σχολή / Faculty of EngineeringΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.source.abbreviationSci Repen
dc.contributor.orcidStylianopoulos, Triantafyllos [0000-0002-3093-1696]
dc.contributor.orcidAlexopoulos, Leonidas G. [0000-0003-0425-166X]

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