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dc.contributor.authorMartin, John D.en
dc.contributor.authorPanagi, Myroforaen
dc.contributor.authorWang, Chenyuen
dc.contributor.authorKhan, Thahomina T.en
dc.contributor.authorMartin, Margaret R.en
dc.contributor.authorVoutouri, Chrysovalantisen
dc.contributor.authorToh, Kazukoen
dc.contributor.authorPapageorgis, Panagiotisen
dc.contributor.authorMpekris, Fotiosen
dc.contributor.authorPolydorou, Christianaen
dc.contributor.authorIshii, Genichiroen
dc.contributor.authorTakahashi, Shinichiroen
dc.contributor.authorGotohda, Naotoen
dc.contributor.authorSuzuki, Toshiyukien
dc.contributor.authorWilhelm, Matthew E.en
dc.contributor.authorMelo, Vinicio Alejandroen
dc.contributor.authorQuader, Sabinaen
dc.contributor.authorNorimatsu, Jumpeien
dc.contributor.authorLanning, Ryan M.en
dc.contributor.authorKojima, Motohiroen
dc.contributor.authorStuber, Matthew Daviden
dc.contributor.authorStylianopoulos, Triantafyllosen
dc.contributor.authorKataoka, Kazunorien
dc.contributor.authorCabral, Horacioen
dc.creatorMartin, John D.en
dc.creatorPanagi, Myroforaen
dc.creatorWang, Chenyuen
dc.creatorKhan, Thahomina T.en
dc.creatorMartin, Margaret R.en
dc.creatorVoutouri, Chrysovalantisen
dc.creatorToh, Kazukoen
dc.creatorPapageorgis, Panagiotisen
dc.creatorMpekris, Fotiosen
dc.creatorPolydorou, Christianaen
dc.creatorIshii, Genichiroen
dc.creatorTakahashi, Shinichiroen
dc.creatorGotohda, Naotoen
dc.creatorSuzuki, Toshiyukien
dc.creatorWilhelm, Matthew E.en
dc.creatorMelo, Vinicio Alejandroen
dc.creatorQuader, Sabinaen
dc.creatorNorimatsu, Jumpeien
dc.creatorLanning, Ryan M.en
dc.creatorKojima, Motohiroen
dc.creatorStuber, Matthew Daviden
dc.creatorStylianopoulos, Triantafyllosen
dc.creatorKataoka, Kazunorien
dc.creatorCabral, Horacioen
dc.date.accessioned2021-01-27T10:17:54Z
dc.date.available2021-01-27T10:17:54Z
dc.date.issued2019
dc.identifier.issn1936-086X
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/63831
dc.description.abstractDexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various side effects of chemo-, radio-, and immunotherapies. Here, we investigate the tumor microenvironment (TME)-normalizing effects of dexamethasone in metastatic murine breast cancer (BC). Dexamethasone normalizes vessels and the extracellular matrix, thereby reducing interstitial fluid pressure, tissue stiffness, and solid stress. In turn, the penetration of 13 and 32 nm dextrans, which represent nanocarriers (NCs), is increased. A mechanistic model of fluid and macromolecule transport in tumors predicts that dexamethasone increases NC penetration by increasing interstitial hydraulic conductivity without significantly reducing the effective pore diameter of the vessel wall. Also, dexamethasone increases the tumor accumulation and efficacy of ∼30 nm polymeric micelles containing cisplatin (CDDP/m) against murine models of primary BC and spontaneous BC lung metastasis, which also feature a TME with abnormal mechanical properties. These results suggest that pretreatment with dexamethasone before NC administration could increase efficacy against primary tumors and metastases.en
dc.language.isoengen
dc.sourceACS nanoen
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/31187975
dc.titleDexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironmenten
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1021/acsnano.8b07865
dc.description.volume13
dc.description.issue6
dc.description.startingpage6396
dc.description.endingpage6408
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.source.abbreviationACS Nanoen
dc.contributor.orcidStylianopoulos, Triantafyllos [0000-0002-3093-1696]
dc.contributor.orcidMpekris, Fotios [0000-0002-7125-4062]
dc.contributor.orcidPapageorgis, Panagiotis [0000-0002-7595-5616]
dc.contributor.orcidVoutouri, Chrysovalantis [0000-0003-3172-9489]
dc.gnosis.orcid0000-0002-3093-1696
dc.gnosis.orcid0000-0002-7125-4062
dc.gnosis.orcid0000-0002-7595-5616
dc.gnosis.orcid0000-0003-3172-9489


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