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dc.contributor.authorGórriz, Juan M.en
dc.contributor.authorRamírez, Javieren
dc.contributor.authorSegovia, F.en
dc.contributor.authorMartínez, Francisco J.en
dc.contributor.authorLai, Meng-Chuanen
dc.contributor.authorLombardo, Michael V.en
dc.contributor.authorBaron-Cohen, Simonen
dc.contributor.authorMRC AIMS Consortiumen
dc.contributor.authorSuckling, Johnen
dc.creatorGórriz, Juan M.en
dc.creatorRamírez, Javieren
dc.creatorSegovia, F.en
dc.creatorMartínez, Francisco J.en
dc.creatorLai, Meng-Chuanen
dc.creatorLombardo, Michael V.en
dc.creatorBaron-Cohen, Simonen
dc.creatorMRC AIMS Consortiumen
dc.creatorSuckling, Johnen
dc.description.abstractAlthough much research has been undertaken, the spatial patterns, developmental course, and sexual dimorphism of brain structure associated with autism remains enigmatic. One of the difficulties in investigating differences between the sexes in autism is the small sample sizes of available imaging datasets with mixed sex. Thus, the majority of the investigations have involved male samples, with females somewhat overlooked. This paper deploys machine learning on partial least squares feature extraction to reveal differences in regional brain structure between individuals with autism and typically developing participants. A four-class classification problem (sex and condition) is specified, with theoretical restrictions based on the evaluation of a novel upper bound in the resubstitution estimate. These conditions were imposed on the classifier complexity and feature space dimension to assure generalizable results from the training set to test samples. Accuracies above 80 % on gray and white matter tissues estimated from voxel-based morphometry (VBM) features are obtained in a sample of equal-sized high-functioning male and female adults with and without autism (N=120, n=30/group). The proposed learning machine revealed how autism is modulated by biological sex using a low-dimensional feature space extracted from VBM. In addition, a spatial overlap analysis on reference maps partially corroborated predictions of the "extreme male brain" theory of autism, in sexual dimorphic areas.en
dc.sourceInternational Journal of Neural Systemsen
dc.titleA Machine Learning Approach to Reveal the NeuroPhenotypes of Autismsen
dc.description.issue7Σχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and EducationΤμήμα Ψυχολογίας / Department of Psychology
dc.source.abbreviationInt J Neural Systen
dc.contributor.orcidLombardo, Michael V. [0000-0001-6780-8619]

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