Show simple item record

dc.contributor.authorLombardo, Michael V.en
dc.contributor.authorPramparo, Tizianoen
dc.contributor.authorGazestani, Vahiden
dc.contributor.authorWarrier, Varunen
dc.contributor.authorBethlehem, Richard A. I.en
dc.contributor.authorCarter Barnes, Cynthiaen
dc.contributor.authorLopez, Lindaen
dc.contributor.authorLewis, Nathan E.en
dc.contributor.authorEyler, Lisaen
dc.contributor.authorPierce, Karenen
dc.contributor.authorCourchesne, Ericen
dc.creatorLombardo, Michael V.en
dc.creatorPramparo, Tizianoen
dc.creatorGazestani, Vahiden
dc.creatorWarrier, Varunen
dc.creatorBethlehem, Richard A. I.en
dc.creatorCarter Barnes, Cynthiaen
dc.creatorLopez, Lindaen
dc.creatorLewis, Nathan E.en
dc.creatorEyler, Lisaen
dc.creatorPierce, Karenen
dc.creatorCourchesne, Ericen
dc.date.accessioned2021-01-28T12:27:37Z
dc.date.available2021-01-28T12:27:37Z
dc.date.issued2018
dc.identifier.issn1546-1726
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/64021
dc.description.abstractHeterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD.en
dc.language.isoenen
dc.sourceNature Neuroscienceen
dc.source.urihttps://www.nature.com/articles/s41593-018-0281-3
dc.titleLarge-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41593-018-0281-3
dc.description.volume21
dc.description.issue12
dc.description.startingpage1680
dc.description.endingpage1688
dc.author.facultyΣχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and Education
dc.author.departmentΤμήμα Ψυχολογίας / Department of Psychology
dc.type.uhtypeArticleen
dc.contributor.orcidLombardo, Michael V. [0000-0001-6780-8619]
dc.contributor.orcidBethlehem, Richard A. I. [0000-0002-0714-0685]
dc.gnosis.orcid0000-0001-6780-8619
dc.gnosis.orcid0000-0002-0714-0685


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record