Convection-Enhanced Delivery for the treatment of brain cancer
PublisherΠανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering
Place of publicationCyprus
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Effective cancer treatment, especially in the brain, remains a formidable challenge in the field of oncology. Convection-enhanced delivery (CED) is an innovative and promising local drug delivery method for brain cancer, overcoming the challenges of conventional methods. The project develops a mathematical and computational model for brain cancer treatment to predict the drug concentration distributions, applying engineering and physical sciences principles to medicine. In this in silico study, an individualized, three-dimensional finite element model of the brain is used to investigate the CED for the treatment of brain cancer. The model incorporates nonlinear biomechanics, which describes the distribution of the drug concentrations using diluted species transport equations and applying the theory for hindered transport of rigid solutes. The aim of this work is to investigate the drug concentration during CED of different drug sizes by changing the pathophysiological conditions of the tumor tissue. To achieve this, different drug and tumor vessel wall pore sizes and various tumor interstitial space hydraulic conductivity values have been considered to account for a range of drug physicochemical and tumor microenvironment properties. To our knowledge, this present work reports for the first time directly how the size of the vascular wall pores and that of the therapeutic agent affect drug distribution during and after CED. These predictive outcomes provide further and useful insights of the spatial distribution and the average drug concentration in the tumor towards an effective treatment of brain cancer.