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Browsing by Subject "Biochemistry"

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    • Article  

      Cancers of unknown primary site: ESMO Clinical Recommendations for diagnosis, treatment and follow-up 

      Briassoulis, E. Ch; Pavlidis, Nicholas (2007)

    • Article  

      Clinical picture: Acquired icthyosis: A paraneoplastic skin manifestation of Hodgkin's disease 

      Rizos, E.; Milionis, Haralampos J.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)

    • Article  

      Computational Inhibition Studies of the Human Proteasome by Argyrin‐Based Analogues with Subunit Specificity 

      Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D. (2014)

    • Article  

      Direct detection of Fe(IV)=O intermediates in the cytochrome aa3 oxidase from Paracoccus denitrificans[H2O2 reaction 

      Pinakoulaki, Eftychia; Pfitzner, U.; Ludwig, B.; Varotsis, Constantinos (2003)
      We report the first evidence for the formation of the "607- and 580-nm forms" in the cytochrome oxidase aa3/H2O2 reaction without the involvement of tyrosine 280. The pKa of the 607-580-nm transition is 7.5. The 607-nm ...

    • Article  

      Discovery of anti-cancer activity for benzo1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition 

      Sweeney, Martin; Coyle, Robert; Kavanagh, Paul; Berezin, Andrey A.; Lo Re, Daniele; Zissimou, Georgia A.; Koutentis, Panayiotis Andreas; Carty, Michael P.; Aldabbagh, Fawaz (2016)

    • Article  

      First Trimester Noninvasive Prenatal Diagnosis: A Computational Intelligence Approach 

      Neocleous, Andreas C.; Nicolaides, Kypros H.; Schizas, Christos N. (2016)
      The objective of this study is to examine the potential value of using machine learning techniques such as artificial neural network (ANN) schemes for the noninvasive estimation, at 11-13 weeks of gestation, the risk for ...

    • Article  

      Fourier transform infrared (FTIR) and step-scan time-resolved FTIR spectroscopies reveal a unique active site in cytochrome caa3 oxidase from Thermus thermophilus 

      Pinakoulaki, Eftychia; Soulimane, T.; Varotsis, Constantinos (2002)
      Fourier transform infrared (FTIR) and step-scan time-resolved FTIR difference spectra are reported for the [carbonmonoxy]cytochrome caa3 from Thermus thermophilus. A major C-O mode of heme a3 at 1958 cm-1 and two minor ...

    • Article  

      Interaction of metal complexes with G-quadruplex DNA 

      Georgiades, Savvas N.; Abd Karim, N. H.; Suntharalingam, K.; Vilar, R. (2010)
      [Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several ...

    • Article  

      Nitric-oxide reductase: Structure and properties of the catalytic site from resonance Raman scattering 

      Pinakoulaki, Eftychia; Gemeinhardt, S.; Saraste, M.; Varotsis, Constantinos (2002)
      We have applied resonance Raman spectroscopy to investigate the properties of the dinuclear center of oxidized, reduced, and NO-bound nitric-oxide reductase from Paracoccus denitrificans. The spectra of the oxidized enzyme ...

    • Article  

      Observation of the equilibrium CuB-CO complex and functional implications of the transient heme a3 propionates in cytochrome ba3-CO from Thermus thermophilus. Fourier transform infrared (FTIR) and time-resolved step-scan FTIR studies 

      Koutsoupakis, Constantinos; Stavrakis, Stavros; Pinakoulaki, Eftychia; Soulimane, T.; Varotsis, Constantinos (2002)
      We report the first evidence for the existence of the equilibrium CuB 1+-CO species of CO-bound reduced cytochrome ba3 from Thermus thermophilus at room temperature. The frequency of the C-O stretching mode of CuB 1+-CO ...

    • Article  

      Paraganglioma of cauda equina 

      Iliadis, Charalambos; Kirgiannis, Kosmas; Wozniak, Greta; Vlychou, M.; Santarius, T.; Kirollos, Ramez W. (2008)
      The clinical, radiological and pathological features of a paraganglioma resulting in cauda equina syndrome are described, including magnetic resonance imaging features. The literature is reviewed and discussed.

    • Article  

      Predicting the acid/base behavior of proteins: A constant-pH monte carlo approach with generalized born solvent 

      Aleksandrov, A.; Polydorides, Savvas; Archontis, Georgios Z.; Simonson, T. (2010)
      The acid/base properties of proteins are essential in biochemistry, and proton binding is a valuable reporter on electrostatic interactions. We propose a constant-pH Monte Carlo strategy to compute protonation free energies ...

    • Article  

      Robotic rehabilitation of people with multiple sclerosis with the use of a haptic nine-hole pegboard test 

      Xydas, E. G.; Louca, Loucas S. (2012)
      Multiple Sclerosis (MS) is a complex neurological disease that destroys the myelin sheath of the nerves, consequently affecting the motor control ability in numerous ways. It has been shown that people with MS have the ...

    • Article  

      The role of the cross-link His-Tyr in the functional properties of the binuclear center in cytochrome c oxidase 

      Pinakoulaki, Eftychia; Pfitzner, U.; Ludwig, B.; Varotsis, Constantinos (2002)
      Resonance Raman and Fourier transform infrared spectroscopies have been used to study the aa3-type cytochrome c oxidase and the Y280H mutant from Paracoccus denitrificans. The stability of the binuclear center in the absence ...

    • Article  

      Simultaneous resonance Raman detection of the heme a3-Fe-CO and CuB-CO species in CO-bound ba3-cytochrome c oxidase from Thermus thermophilus: Evidence for a charge transfer CuB-CO transition 

      Pinakoulaki, Eftychia; Ohta, T.; Soulimane, T.; Kitagawa, T.; Varotsis, Constantinos (2004)
      Understanding of the chemical nature of the dioxygen and nitric oxide moiety of ba3-cytochrome c oxidase from Thermus thermophilus is crucial for elucidation of its physiological function. In the present work, direct ...

    • Article  

      Spin Crossover in Nitrito-Myoglobin as Revealed by Resonance Raman Spectroscopy 

      Lambrou, Alexandra; Ioannou, Androulla; Pinakoulaki, Eftychia (2016)
      The myoglobin (Mb) heme Fe-O-N=O and heme Fe-O-N=O/2-nitrovinyl species have been characterized by resonance Raman spectroscopy. In the heme Fe-O-N=O species, the bound nitrite ligand is removed by solvent exchange, thus ...

    • Article  

      Studiu in Vitro Al Hemangioamelor Cutanate Ale Copilariei 

      Vezan, Remus N.; Paraina, Ioan; Zachariou, Zacharias (2009)
      Hemangiomas are the most common tumor of infancy and are caracterized by a initial rapid growth followed by a slow involution. We raport a novel human in vitro model for hemangioma tissues. Our aim is to abtain small ...

    • Doctoral Thesis  Open Access

      Κλωνοποίηση και χαρακτηρισμός της πρωτεϊνης κινητήρα KIFC5A: ο πόλος της στη μιτωτική διαίρεση και η εμπλοκή της στο μηχανισμό διπλασιασμού του κεντροσωματίου 

      Χριστοδούλου, Ανδρούλα (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2006-06)
      Η παρούσα διδακτορική Διατριβή περιγράφει την ταυτοποίηση και το λειτουργικό χαρακτηρισμό της πρωτεΐνης κινητήρα τύπου κινησίνης, KIFC5A του ποντικού. Ο λειτουργικός χαρακτηρισμός της KIFC5A με συνδυασμό τεχνικών μοριακής, ...

    • Doctoral Thesis  Open Access

      Λειτουργικός χαρακτηρισμός της πρωτεϊνης - κινητήρα KIF1Bβ στους νευρώνες 

      Χαραλάμπους, Δέσποινα (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2011-12)
      Η παρούσα Διδακτορική Διατριβή επιζητεί την ταυτοποίηση και το λειτουργικό χαρακτηρισμό της πρωτεΐνης κινητήρα τύπου κινησίνης, KIF1Bβ του ποντικού. Ο λειτουργικός χαρακτηρισμός της KIF1Bβ με συνδυασμό τεχνικών μοριακής, ...

    • Doctoral Thesis  Open Access

      Μελέτη της δραστικότητας και κινητικής ρευστότητας σκληρών μεταλλοϊόντων με ηλεκτροχημικά ενεργούς υποκαταστάτες 

      Ρίκκου, Μαρία Π. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2006-06)
      Αντίδραση μη όξο δικετονικών ενώσεων του βαναδίου(IV) με ετεροαζοαρωματικούς υποκατάστατες είχε ως αποτέλεσμα την αναγωγή των ενώσεων του βαναδίου(VI) σε οκταεδρικές ενώσεις του βαναδίου(III) με ταυτόχρονη οξείδωση της ...

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