Browsing by Subject "Biochemistry"

Article

Cancers of unknown primary site: ESMO Clinical Recommendations for diagnosis, treatment and follow-up

Briassoulis, E. Ch; Pavlidis, Nicholas (2007)

Article

Clinical picture: Acquired icthyosis: A paraneoplastic skin manifestation of Hodgkin's disease

Rizos, E.; Milionis, Haralampos J.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)

Article

Computational Inhibition Studies of the Human Proteasome by Argyrin‐Based Analogues with Subunit Specificity

Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D. (2014)

Article

Direct detection of Fe(IV)=O intermediates in the cytochrome aa3 oxidase from Paracoccus denitrificans[H2O2 reaction

Pinakoulaki, Eftychia; Pfitzner, U.; Ludwig, B.; Varotsis, Constantinos (2003)

We report the first evidence for the formation of the "607- and 580-nm forms" in the cytochrome oxidase aa3/H2O2 reaction without the involvement of tyrosine 280. The pKa of the 607-580-nm transition is 7.5. The 607-nm ...

Article

Discovery of anti-cancer activity for benzo1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition

Sweeney, Martin; Coyle, Robert; Kavanagh, Paul; Berezin, Andrey A.; Lo Re, Daniele; Zissimou, Georgia A.; Koutentis, Panayiotis Andreas; Carty, Michael P.; Aldabbagh, Fawaz (2016)

Article

First Trimester Noninvasive Prenatal Diagnosis: A Computational Intelligence Approach

Neocleous, Andreas C.; Nicolaides, Kypros H.; Schizas, Christos N. (2016)

The objective of this study is to examine the potential value of using machine learning techniques such as artificial neural network (ANN) schemes for the noninvasive estimation, at 11-13 weeks of gestation, the risk for ...

Article

Fourier transform infrared (FTIR) and step-scan time-resolved FTIR spectroscopies reveal a unique active site in cytochrome caa3 oxidase from Thermus thermophilus

Pinakoulaki, Eftychia; Soulimane, T.; Varotsis, Constantinos (2002)

Fourier transform infrared (FTIR) and step-scan time-resolved FTIR difference spectra are reported for the [carbonmonoxy]cytochrome caa3 from Thermus thermophilus. A major C-O mode of heme a3 at 1958 cm-1 and two minor ...

Article

Interaction of metal complexes with G-quadruplex DNA

Georgiades, Savvas N.; Abd Karim, N. H.; Suntharalingam, K.; Vilar, R. (2010)

[Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several ...

Article

Nitric-oxide reductase: Structure and properties of the catalytic site from resonance Raman scattering

Pinakoulaki, Eftychia; Gemeinhardt, S.; Saraste, M.; Varotsis, Constantinos (2002)

We have applied resonance Raman spectroscopy to investigate the properties of the dinuclear center of oxidized, reduced, and NO-bound nitric-oxide reductase from Paracoccus denitrificans. The spectra of the oxidized enzyme ...

Article

Observation of the equilibrium CuB-CO complex and functional implications of the transient heme a3 propionates in cytochrome ba3-CO from Thermus thermophilus. Fourier transform infrared (FTIR) and time-resolved step-scan FTIR studies

Koutsoupakis, Constantinos; Stavrakis, Stavros; Pinakoulaki, Eftychia; Soulimane, T.; Varotsis, Constantinos (2002)

We report the first evidence for the existence of the equilibrium CuB 1+-CO species of CO-bound reduced cytochrome ba3 from Thermus thermophilus at room temperature. The frequency of the C-O stretching mode of CuB 1+-CO ...

Article

Paraganglioma of cauda equina

Iliadis, Charalambos; Kirgiannis, Kosmas; Wozniak, Greta; Vlychou, M.; Santarius, T.; Kirollos, Ramez W. (2008)

The clinical, radiological and pathological features of a paraganglioma resulting in cauda equina syndrome are described, including magnetic resonance imaging features. The literature is reviewed and discussed.

Article

Predicting the acid/base behavior of proteins: A constant-pH monte carlo approach with generalized born solvent

Aleksandrov, A.; Polydorides, Savvas; Archontis, Georgios Z.; Simonson, T. (2010)

The acid/base properties of proteins are essential in biochemistry, and proton binding is a valuable reporter on electrostatic interactions. We propose a constant-pH Monte Carlo strategy to compute protonation free energies ...

Article

Robotic rehabilitation of people with multiple sclerosis with the use of a haptic nine-hole pegboard test

Xydas, E. G.; Louca, Loucas S. (2012)

Multiple Sclerosis (MS) is a complex neurological disease that destroys the myelin sheath of the nerves, consequently affecting the motor control ability in numerous ways. It has been shown that people with MS have the ...

Article

The role of the cross-link His-Tyr in the functional properties of the binuclear center in cytochrome c oxidase

Pinakoulaki, Eftychia; Pfitzner, U.; Ludwig, B.; Varotsis, Constantinos (2002)

Resonance Raman and Fourier transform infrared spectroscopies have been used to study the aa3-type cytochrome c oxidase and the Y280H mutant from Paracoccus denitrificans. The stability of the binuclear center in the absence ...

Article

Simultaneous resonance Raman detection of the heme a3-Fe-CO and CuB-CO species in CO-bound ba3-cytochrome c oxidase from Thermus thermophilus: Evidence for a charge transfer CuB-CO transition

Pinakoulaki, Eftychia; Ohta, T.; Soulimane, T.; Kitagawa, T.; Varotsis, Constantinos (2004)

Understanding of the chemical nature of the dioxygen and nitric oxide moiety of ba3-cytochrome c oxidase from Thermus thermophilus is crucial for elucidation of its physiological function. In the present work, direct ...

Article

Spin Crossover in Nitrito-Myoglobin as Revealed by Resonance Raman Spectroscopy

Lambrou, Alexandra; Ioannou, Androulla; Pinakoulaki, Eftychia (2016)

The myoglobin (Mb) heme Fe-O-N=O and heme Fe-O-N=O/2-nitrovinyl species have been characterized by resonance Raman spectroscopy. In the heme Fe-O-N=O species, the bound nitrite ligand is removed by solvent exchange, thus ...

Article

Studiu in Vitro Al Hemangioamelor Cutanate Ale Copilariei

Vezan, Remus N.; Paraina, Ioan; Zachariou, Zacharias (2009)

Hemangiomas are the most common tumor of infancy and are caracterized by a initial rapid growth followed by a slow involution. We raport a novel human in vitro model for hemangioma tissues. Our aim is to abtain small ...

Doctoral Thesis Open Access

Κλωνοποίηση και χαρακτηρισμός της πρωτεϊνης κινητήρα KIFC5A: ο πόλος της στη μιτωτική διαίρεση και η εμπλοκή της στο μηχανισμό διπλασιασμού του κεντροσωματίου

Χριστοδούλου, Ανδρούλα (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2006-06)

Η παρούσα διδακτορική Διατριβή περιγράφει την ταυτοποίηση και το λειτουργικό χαρακτηρισμό της πρωτεΐνης κινητήρα τύπου κινησίνης, KIFC5A του ποντικού. Ο λειτουργικός χαρακτηρισμός της KIFC5A με συνδυασμό τεχνικών μοριακής, ...

Doctoral Thesis Open Access

Λειτουργικός χαρακτηρισμός της πρωτεϊνης - κινητήρα KIF1Bβ στους νευρώνες

Χαραλάμπους, Δέσποινα (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2011-12)

Η παρούσα Διδακτορική Διατριβή επιζητεί την ταυτοποίηση και το λειτουργικό χαρακτηρισμό της πρωτεΐνης κινητήρα τύπου κινησίνης, KIF1Bβ του ποντικού. Ο λειτουργικός χαρακτηρισμός της KIF1Bβ με συνδυασμό τεχνικών μοριακής, ...

Doctoral Thesis Open Access

Μελέτη της δραστικότητας και κινητικής ρευστότητας σκληρών μεταλλοϊόντων με ηλεκτροχημικά ενεργούς υποκαταστάτες

Ρίκκου, Μαρία Π. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2006-06)

Αντίδραση μη όξο δικετονικών ενώσεων του βαναδίου(IV) με ετεροαζοαρωματικούς υποκατάστατες είχε ως αποτέλεσμα την αναγωγή των ενώσεων του βαναδίου(VI) σε οκταεδρικές ενώσεις του βαναδίου(III) με ταυτόχρονη οξείδωση της ...