Browsing by Subject "Disease association"

Article

Clear cell ovarian carcinoma in a pregnant woman with a history of infertility, endometriosis and unsuccessful IVF treatment

Makrydimas, G.; Sotiriadis, A.; Paraskevaidis, E.; Pavlidis, Nicholas; Agnantis, Niki J.; Lolis, D. (2003)

Ovarian cancer in pregnancy is a very rare event. We present here the case of a 37-year-old woman in whom a clear cell ovarian carcinoma was diagnosed in the first trimester of pregnancy. This patient had a history of ...

Article

Clinical picture: Acquired icthyosis: A paraneoplastic skin manifestation of Hodgkin's disease

Rizos, E.; Milionis, Haralampos J.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)

Article

Clinicopathological study of metallothionein immunohistochemical expression, in benign, borderline and malignant ovarian epithelial tumors

Zagorianakou, N.; Stefanou, D. G.; Makrydimas, G.; Zagorianakou, P.; Briassoulis, E. Ch; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2006)

Metallothioneins (MTs) are a family of cystein-rich metal-binding proteins, which are expressed in normal cells during fetal and postnatal life but also in a variety of human neoplasms. MT expression in human tumors has ...

Article

Depression in cancer: The many biobehavioral pathways driving tumor progression

Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)

Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...

Article

Economic recession and emergence of an HIV-1 outbreak among drug injectors in Athens metropolitan area: A longitudinal study

Paraskeva, D.; Nikolopoulos, Georgios K.; Fotiou, Anastasios; Tsiara, Chrissa G.; Paraskeva, D.; Sypsa, V.; Lazanas, Marios; Gargalianos, Panagiotis; Psichogiou, M.; Skoutelis, A.; Wiessing, L.; Friedman, Samuel R.; Jarlais, Don C. Des; Terzidou, M.; Kremastinou, Jenny; Malliori-Minerva, Melpomeni; Hatzakis, A. (2013)

Background: During 2011, a dramatic increase (1600%) of reported HIV-1 infections among injecting drug users (IDUs) was noted in Athens, Greece. We herein assess the potential causal pathways associated with this outbreak. ...

Article

Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome

Tsantes, Argirio E.; Kopterides, Petros; Bonovas, Stefanos; Bagos, Pantelis G.; Antonakos, Georgios; Nikolopoulos, Georgios K.; Gialeraki, Argiri; Kapsimali, Violetta; Kyriakou, Elias; Kokoris, Styliani; Dima, Kleanthi; Armaganidis, Apostolos; Tsangaris, I. (2013)

Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ...

Article

Endobronchial metastases secondary to solid tumors: Report of eight cases and review of the literature

Katsimbri, P. P.; Bamias, A. T.; Froudarakis, M. E.; Peponis, I. A.; Constantopoulos, S. H.; Pavlidis, Nicholas (2000)

Endobronchial metastases (EBM) secondaries to extrapulmonary solid malignant tumors are rare. Breast, colon and renal adenocarcinomas are the most frequent tumors associated with EBM. Since 1990 we have treated eight ...

Article

ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of malignant glioma

Stupp, Roger; Pavlidis, Nicholas; Jelic, S. (2005)

Article

Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece

Nikolopoulos, Georgios K.; Katsoulidou, Antigoni; Kantzanou, Maria; Rokka, C.; Tsiara, Chrissa G.; Sypsa, V.; Paraskeva, D.; Psichogiou, M.; Friedman, Samuel R.; Hatzakis, A. (2017)

This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical ...

Article

High levels of topoisomerase IIα protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment

Pentheroudakis, George; Goussia, Anna; Voulgaris, E.; Nikolaides, C.; Ioannidou, E.; Papoudou-Bai, A.; Grepi, K.; Kanavaros, P.; Pavlidis, Nicholas; Bai, M. C. (2010)

Gene copy number and protein expression of topoisomerase IIα were correlated to benefit from anthracyclines in various tumors. A retrospective series of 69 patients with DLBCL managed with CHOP chemotherapy were studied ...

Article

Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: Incidence, correlations and prognostic utility

Stoyianni, A.; Goussia, Anna; Pentheroudakis, George; Siozopoulou, V.; Ioachim, E.; Krikelis, D.; Golfinopoulos, Vassilis; Cervantes, A.; Bobos, M.; Fotsis, T.; Bellou, S.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)

Background: The epithelial to mesenchymal transition (EMT) has been associated with metastatic dissemination and poor outcome in several solid tumour types. Our aim was to study its incidence and its prognostic significance ...

Article

Inflammatory prostate cancer: An underestimated paraneoplastic clinical manifestation

Mauri, D.; Pentheroudakis, George; Ch, F. Tolis; Chojnacka, M.; Pavlidis, Nicholas (2005)

Purpose: To identify the incidence of prostate cancer associated-systemic inflammatory syndrome (SIS), and to characterize further this entity, we searched our database as well as the medical literature. Methods: We ...

Article

Intracellular signalling via the AKT axis and downstream effectors is active and prognostically significant in cancer of unknown primary (CUP): A study of 100 CUP cases

Golfinopoulos, Vassilis; Pentheroudakis, George; Goussia, Anna; Siozopoulou, V.; Bobos, M.; Krikelis, D.; Cervantes, A.; Ciuleanu, T.; Marselos, M.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)

Background: Hypothesising that cancer of unknown primary (CUP) may harbour unique characteristics, we present a translational study of the immunohistochemical expression and clinical correlation of key PTEN/AKT pathway ...

Article

Is androgen substitution necessary in hypogonadal patients when they are treated with chemotherapy for malignant diseases?

Pavlidis, Nicholas; Nikolaou, N.; Ch, F. Tolis; Orfanos, S.; Tolis, G. (1989)

A patient with hypogonadotropic hypogonadism owing to endogenous gonadotropin releasing hormone deficiency, who developed Hodgkin's disease is described. Chemotherapy administration caused prolonged and life‐threatening ...

Article

Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis

Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Vaiopoulos, G.; Travlou, Anthi S. (2007)

Background: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism ...

Article

Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature

Kamposioras, K.; Pentheroudakis, George; Pectasides, Dimitrios; Pavlidis, Nicholas (2011)

Introduction: Although more than 90% of melanomas have a cutaneous origin, occasionally it is discovered as a secondary deposit without evident primary site. The aim of this study was to systematically review published ...

Article

Management of leptomeningeal malignancy

Pentheroudakis, George; Pavlidis, Nicholas (2005)

Leptomeningeal carcinomatosis is defined as malignant infiltration of the pia matter and arachnoid membrane. Leukaemias and lymphomas, lung, breast cancer and melanoma are the primary tumours commonly associated with ...

Article

Metabolic syndrome and its components as predictors of ischemic stroke in type 2 diabetic patients

Protopsaltis, I. D.; Korantzopoulos, Panagiotis; Milionis, Haralampos J.; Koutsovasilis, Anastasios; Nikolopoulos, Georgios K.; Dimou, Eftihia; Kokkoris, Stelios; Brestas, Paris; Elisaf, Moses S.; Melidonis, Andreas (2008)

BACKGROUND AND PURPOSE - The available data regarding the association between metabolic syndrome (MS) or MS components and ischemic stroke in type 2 diabetics are limited and inconsistent. This study aimed to investigate ...

Article

Network characteristics of people who inject drugs within a new HIV epidemic following austerity in Athens, Greece

Tsang, M. A.; Schneider, J. A.; Sypsa, V.; Schumm, P.; Nikolopoulos, Georgios K.; Paraskeva, D.; Friedman, Samuel R.; Malliori-Minerva, Melpomeni; Hatzakis, A. (2015)

Background: Greece experienced an unprecedented increase in HIV cases among drug injectors in 2011 after economic crisis. Network-level factors are increasingly understood to drive HIV transmission in emerging epidemics. ...

Article

Optimal therapeutic management of patients with distinct clinicopathological cancer of unknown primary subsets

Pavlidis, Nicholas (2012)

Cancer of unknown primary sites (CUP) is a compilation of various malignant entities-the majority of which behave aggressively and carry poor prognosis. CUP is classified into two different clinicopathological groups: the ...