Browsing by Subject "Gene frequency"
Now showing items 1-11 of 11
-
Article
Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes?
(2002)Background: Tamoxifen has favorable effects on the serum lipid profile. It has been suggested that the apolipoprotein (Apo) E phenotype can influence serum lipid parameters; the ApoE allele 4 (ApoE4) is associated with ...
-
Article
Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis
(2007)The effect of the 675 insertion/deletion (4G/5G) polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene on the risk of venous thromboembolism (VTE) remains controversial. In this study, we performed a meta-analysis ...
-
Article
Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: A Hellenic Cooperative Oncology Group study
(2012)Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T ...
-
Article
The GNB3 C825T polymorphism and essential hypertension: A meta-analysis of 34 studies including 14 094 cases and 17 760 controls
(2007)OBJECTIVES: The C825T single nucleotide polymorphism of the G-protein β3 (GNB3) has been implicated in susceptibility to essential hypertension, through the expression of an alternatively spliced truncated variant. In an ...
-
Article
Impact of ACE and ApoE polymorphisms on myocardial perfusion: Correlation with myocardial single photon emission computed tomographic imaging
(2009)Coronary artery disease is associated with multiple genetic and environmental risk factors. In this study, we evaluated the correlation of angiotensin l-converting enzyme (ACE) (I/D) and ApoE gene polymorphisms (E2, E3, ...
-
Article
Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis
(2007)Introduction: Platelet adhesion to fibrillar collagen via the membrane glycoprotein (GP) Ia/IIa (α2β1), is a crucial event in the pathogenesis of arterial occlusive disorders. The C807T single nucleotide polymorphism of ...
-
Article
KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: A cohort study
(2014)Objectives: Treatment decision-making in colorectal cancer is often guided by tumour tissue molecular analysis. The aim of this study was the development and validation of a high-resolution melting (HRM) method for the ...
-
Article
Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis
(2007)Background: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism ...
-
Article
No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysis
(2007)We conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies ...
-
Article
Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: A meta-analysis
(2007)This study investigated the hypothesis that the insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor type-1 gene affects the risk for ischemic stroke, since results concerning this association ...
-
Article
Serous papillary peritoneal carcinoma: Unknown primary tumour, ovarian cancer counterpart or a distinct entity? A systematic review
(2010)Introduction: Serous peritoneal papillary carcinoma (SPPC), though managed according to ovarian cancer therapeutic principles, has been variably considered as an ovarian cancer counterpart, a peritoneal malignancy with ...