Browsing by Subject "Genetic variability"
Now showing items 1-4 of 4
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Article
Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls
(2011)Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ...
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Article
The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis
(2010)Background. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis ...
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Article
The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk
(2008)Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma ...
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Article
A twisted kiss: In vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer
(2010)KiSS-1 is a metastasis suppressor gene, its inactivation linked to advanced tumor stage and dismal prognosis. We studied its mutational status, transcription and protein expression in human cancer cell lines and patients ...