The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk
Date
2008Author
Tsantes, Argirio E.Nikolopoulos, Georgios K.
Bagos, Pantelis G.
Bonovas, Stefanos
Kopterides, Petros
Vaiopoulos, G.
Source
Thrombosis researchVolume
122Issue
6Pages
736-742Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma PAI-1. The 4G allele is associated with higher levels of PAI-1, and might increase the risk for intravascular thrombosis. However, the contribution of this genetic variant to the risk for thrombosis, both arterial and venous, has not been clearly established. A broad spectrum of findings regarding the effect of the 4G allele on thrombotic risk in different target organs has been reported. Our aim is to summarize the variable influence of this polymorphism on thrombotic events in different tissues or organs and explain the underlying mechanisms accounting for these differences. © 2007 Elsevier Ltd. All rights reserved.