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dc.contributor.authorTsantes, Argirio E.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorBagos, Pantelis G.en
dc.contributor.authorBonovas, Stefanosen
dc.contributor.authorKopterides, Petrosen
dc.contributor.authorVaiopoulos, G.en
dc.creatorTsantes, Argirio E.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorBagos, Pantelis G.en
dc.creatorBonovas, Stefanosen
dc.creatorKopterides, Petrosen
dc.creatorVaiopoulos, G.en
dc.date.accessioned2018-06-22T09:53:24Z
dc.date.available2018-06-22T09:53:24Z
dc.date.issued2008
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41815
dc.description.abstractPlasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma PAI-1. The 4G allele is associated with higher levels of PAI-1, and might increase the risk for intravascular thrombosis. However, the contribution of this genetic variant to the risk for thrombosis, both arterial and venous, has not been clearly established. A broad spectrum of findings regarding the effect of the 4G allele on thrombotic risk in different target organs has been reported. Our aim is to summarize the variable influence of this polymorphism on thrombotic events in different tissues or organs and explain the underlying mechanisms accounting for these differences. © 2007 Elsevier Ltd. All rights reserved.en
dc.language.isoengen
dc.sourceThrombosis researchen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectThrombosisen
dc.subjectReviewen
dc.subjectAlleleen
dc.subjectGenetic susceptibilityen
dc.subjectGenotypeen
dc.subjectHeart infarctionen
dc.subjectPolymorphismen
dc.subjectGeneticen
dc.subjectPromoter regionen
dc.subjectProtein expressionen
dc.subjectCardiovascular risken
dc.subjectDisease severityen
dc.subjectArtery thrombosisen
dc.subject4g/5g polymorphismen
dc.subjectPlasminogen activator inhibitor 1en
dc.subjectGenetic variabilityen
dc.subjectCerebrovascular accidenten
dc.subjectBrain ischemiaen
dc.subjectPai-1en
dc.subjectProtein polymorphismen
dc.subjectStrokeen
dc.subjectThrombotic risken
dc.subjectVein thrombosisen
dc.subjectVenous thromboembolismen
dc.titleThe effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risken
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.thromres.2007.09.005
dc.description.volume122
dc.description.issue6
dc.description.startingpage736
dc.description.endingpage742
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBagos, Pantelis G. [0000-0003-4935-2325]
dc.contributor.orcidBonovas, Stefanos [0000-0001-6102-6579]
dc.contributor.orcidKopterides, Petros [0000-0002-7682-4482]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0003-4935-2325
dc.gnosis.orcid0000-0001-6102-6579
dc.gnosis.orcid0000-0002-7682-4482


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