Browsing by Subject "Mechanical"

Article

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)

Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...

Article

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

Article

Image-based biomechanics of collagen-based tissue equivalents

Barocas, V. Η; Sander, E.; Stylianopoulos, T.; Tranquillo, R. (2009)

Article

Multiscale modelling of solid tumour growth: the effect of collagen micromechanics

Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)

Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...

Article

Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls

Barocas, V. Η; Stylianopoulos, T. (2007)

Passive elastic behavior of arterial wall remains difficult to model. Although phenomenological and structural models exist, the question of how the three-dimensional network structure of the collagen in the artery determines ...

Article

Remodeling of extracellular matrix due to solid stress accumulation during tumor growth

Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)

Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...

Article

Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors

Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)

Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...

Article

The role of mechanical forces in tumor growth and therapy

Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)

Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

Article

The Solid Mechanics of Cancer and Strategies for Improved Therapy

Stylianopoulos, T. (2017)

Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...

Article

Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery

Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)

Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...

Article

A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth

Vavourakis, V.; Wijeratne, P. A.; Shipley, R.; Loizidou, M.; Stylianopoulos, T.; Hawkes, D. J. (2017)

Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...