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Browsing by Subject "Phenotype"

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    • Article  

      Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes? 

      Liberopoulos, E. N.; Karabina, S. A.; Tselepis, A.; Bairaktari, Eleni Th; Nikolaides, C.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)
      Background: Tamoxifen has favorable effects on the serum lipid profile. It has been suggested that the apolipoprotein (Apo) E phenotype can influence serum lipid parameters; the ApoE allele 4 (ApoE4) is associated with ...

    • Article  

      The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)
      Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...

    • Article  

      Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα 

      Aoyama, M.; Grabowski, D. R.; Dubyak, G. R.; Constantinou, Andreas I.; Rybicki, L. A.; Bukowski, R. M.; Ganapathi, M. K.; Hickson, I. D.; Ganapathi, R. (1998)
      Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIα ...

    • Article  

      Cystic fibrosis mutational spectrum and genotypic/phenotypic features in Greek-Cypriots, with emphasis on dehydration as presenting symptom [3] 

      Yiallouros, P. K.; Neocleous, Vassos; Zeniou, M.; Adamidou, Despoina; Costi, Constantina Eleni; Christophi, C.; Tzetis, M.; Kanavakis, E.; Constantinou-Deltas, Constantinos D. (2007)

    • Article  

      The effect of tamoxifen therapy on serum apolipoprotein A-I level is modified by the apolipoprotein E phenotype 

      Liberopoulos, E. N.; Pavlidis, Nicholas; Elisaf, Moses S. (2001)

    • Article  

      Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation 

      Polydorou, Christiana; Georgiades, Pantelis (2013)
      Although extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive ...

    • Article  

      The EU-AIMS Longitudinal European Autism Project (LEAP): Clinical characterisation 

      Charman, T.; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, C.; Goyard, David; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, Tobias; Baron-Cohen,Simon; Baumeister, Sarah; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; De Bruijn, Y.; Chakrabarti,B.; Cornelissen, Ineke; Acqua, Flavio Dell; Dumas, G.; Durston, Sarah; Ecker,C.; Faulkner, J.; Frouin, Vincent; Garces, Pilar; Ham, Lindsay M.; Hayward, Hannah; Hipp, Joerg; Holt, R. J.; Isaksson, Johan; Johnson, Mark H.; Jones, Emily J. H.; Kundu, Prantik; Lai,Meng-Chuan; D'Ardhuy, X. L.; Lombardo,Michael V.; Lythgoe, David J.; Mandl, Rene; Mason, Luke; Meyer-Lindenberg, Andreas; Moessnang, Carolin; Mueller, Nico; O'Dwyer, Laurence; Oldehinkel, Marianne; Oranje, Bob; Pandina, Gahan J.; Persico, Antonio M.; Ruggeri, B.; Ruigrok,Amber N. V.; Sabet, Jessica; Sacco, Roberto; Caceres, Antonia San Jose; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams,Steven C. R.; Zwiers, Marcel P.; Spooren, Will; Murphy,Declan G. M.; Buitelaar, Jan K. (2017)
      Background: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes ...

    • Article  

      Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials 

      Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)
      Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

    • Article  

      Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks 

      Kamposioras, K.; Pentheroudakis, George; Pavlidis, Nicholas (2013)
      Background: Cancer of unknown primary (CUP) ranks among the ten most common malignancies worldwide. Cancer of unknown primary presents as disseminated disease, has a dismal prognosis and remains a diagnosis of exclusion. ...

    • Article  

      Familial C3 Glomerulopathy Associated with CFHR5 Mutations: Clinical Characteristics of 91 Patients in 16 Pedigrees 

      Athanasiou, Yiannis; Voskarides, Konstantinos; Gale, D. P.; Damianou, Loukas; Patsias, Charalambos; Zavros, Michalis; Maxwell, P. H.; Cook, H. T.; Demosthenous, Panayiota; Hadjisavvas, Andreas; Kyriacou, Kyriacos C.; Zouvani, Ioanna; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (2011)
      Background and objectives Complement factor H and related proteins (CFHR) are key regulators of the alternative complement pathway, where loss of function mutations lead to a glomerulopathy with isolated mesangial C3 ...

    • Article  

      Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice 

      Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)
      Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

    • Article  

      Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: Incidence, correlations and prognostic utility 

      Stoyianni, A.; Goussia, Anna; Pentheroudakis, George; Siozopoulou, V.; Ioachim, E.; Krikelis, D.; Golfinopoulos, Vassilis; Cervantes, A.; Bobos, M.; Fotsis, T.; Bellou, S.; Fountzilas, George; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2012)
      Background: The epithelial to mesenchymal transition (EMT) has been associated with metastatic dissemination and poor outcome in several solid tumour types. Our aim was to study its incidence and its prognostic significance ...

    • Article  

      In vivo imaging of quantum dots encapsulated in phospholipid micelles 

      Dubertret, B.; Skourides, Paris A.; Norris, D. J.; Brivanlou, A. H.; Libchaber, A.; Noireaux, V. (2002)
      Fluorescent semiconductor nanocrystals (quantum dots) have the potential to revolutionize biological imaging, but their use has been limited by difficulties in obtaining nanocrystals that are biocompatible. To address this ...

    • Article  

      Insights into the epithelial mesenchymal transition phenotype in cancer of unknown primary from a global microRNA profiling study 

      Stoyianni, A.; Pentheroudakis, George; Benjamin, H.; Cervantes, A.; Ashkenazi, K.; Lazaridis, G.; Pavlidis, Nicholas; Spector, Y. (2014)
      Purpose: We sought to study the microRNA regulation of epithelial mesenchymal transition (EMT), the acquisition of migratory, mesenchymal-like properties of epithelial cells, in cancer of unknown primary (CUP). Patients ...

    • Article  

      Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: Evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta 

      Spotila, L. D.; Constantinou-Deltas, Constantinos D.; Sereda, L.; Ganguly, A.; Riggs, B. L.; Prockop, D. J. (1991)
      Mutations in the two genes for type I collagen (COL1A1 or COL1A2) cause osteogenesis imperfecta (OI), a heritable disease characterized by moderate to extreme brittleness of bone early in life. Here we show that a 52-year-old ...

    • Article  

      Mutations in type I procollagen genes that cause osteogenesis imperfecta 

      Prockop, D. J.; Baldwin, C. T.; Constantinou-Deltas, Constantinos D. (1990)

    • Article  

      PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein 

      Mochizuki, Toshio; Wu, G.; Hayashi, Tomohito; Xenophontos, Stavroulla L.; Veldhuisen, B.; Saris, J. J.; Reynolds, D. M.; Cai, Y.; Gabow, P. A.; Pierides, Alkis M.; Kimberling, W. J.; Breuning, M. H.; Constantinou-Deltas, Constantinos D.; Peters, D. J. M.; Somlo, Stefan (1996)
      A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene (PKD2) segregated with the disease in three PKD2 families. The predicted 968-amino acid ...

    • Article  

      Psychopathic personality traits in 5 year old twins: the importance of genetic and shared environmental influences 

      Tuvblad, Catherine; Fanti, Kostas A.; Andershed, Henrik; Colins, Olivier F.; Larsson, H. (Dr. Dietrich Steinkopff Verlag GmbH and Co. KG, 2017)
      There is limited research on the genetic and environmental bases of psychopathic personality traits in children. In this study, psychopathic personality traits were assessed in a total of 1189 5-year-old boys and girls ...

    • Article  

      A retrospective analysis of serum CA 15-3 concentrations in patients with localised or metastatic renal cancer and its impact on prognosis and follow-up. A single-centre experience 

      Briassoulis, E. Ch; Pentheroudakis, George; Letsa, I.; Pavlidis, Nicholas (2002)
      Background. Monitoring patients with renal cancer for recurrence or progression is ineffective, inconvenient and costly. We conducted a retrospective analysis of serum CA 15-3 concentrations in a single-centre patient ...

    • Article  

      Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer 

      Strati, K.; Lambert, P. F. (2007)
      Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). ...

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