Browsing by Subject "biomechanics"
Now showing items 1-11 of 11
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A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
(2016)Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...
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Article
Covalent amphiphilic polymer networks
(2003)The recent literature on chemically cross-linked amphiphilic polymer networks is reviewed. The main subjects covered are network synthesis, characterization, modeling and applications. Special mention is made to more modern ...
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Evolution of osmotic pressure in solid tumors
(2014)The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...
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FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis
(2014)Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue morphology. Although significant progress has been made in understanding the mechanisms linking the ...
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Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
(2016)Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
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Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls
(2007)Passive elastic behavior of arterial wall remains difficult to model. Although phenomenological and structural models exist, the question of how the three-dimensional network structure of the collagen in the artery determines ...
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Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
(2015)Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...
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Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors
(2014)Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...
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The Solid Mechanics of Cancer and Strategies for Improved Therapy
(2017)Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
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Unsupervided pattern recognition for the classification of EMG signals
(1999)The shapes and firing rates of motor unit action potentials (MUAP's) in an electromyographic (EMG) signal provide an important source of information for the diagnosis of neuromuscular disorders. In order to extract this ...
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A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth
(2017)Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...