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Browsing by Subject "concentration response"

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    • Article  

      1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study 

      Charalambous, Anna; Koyioni, Maria; Antoniades, Ioanna; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, L. S.; Rakitin, O. A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)
      A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline ...

    • Article  

      Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27Kip1-dependent G1/S cell cycle arrest in conjunction with NF-κB activation 

      Batsi, Christina; Markopoulou, Soultana; Kontargiris, Evangelos; Charalambous, Christina; Thomas, Christoforos G.; Christoforidis, Savvas; Kanavaros, Panagiotis E.; Constantinou, Andreas I.; Marcu, Kenneth B.; Kolettas, Evangelos (2009)
      2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain ...

    • Article  

      D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells 

      Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)
      d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...

    • Article  

      Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H) -one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase 

      Catto, M.; Berezin, Andrey A.; Lo Re, D.; Loizou, G.; Demetriades, Marina; De Stradis, A.; Campagna, F.; Koutentis, Panayiotis Andreas; Carotti, A. (2012)
      Alzheimer's disease (AD) onset and progression are associated with the dysregulation of multiple and complex physiological processes and a successful therapeutic approach should therefore address more than one target. Two ...

    • Article  

      Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells 

      Charalambous, Christina; Pitta, Chara A.; Constantinou, Andreas I. (2013)
      Background: Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since the majority of estrogen receptor positive breast cancer ...

    • Article  

      Evaluation of amino acid ester-based ionic liquids as buffer additives in CE for the separation of 2-arylpropionic acids nonsteroidal anti-inflammatory drugs 

      Mavroudi, Maria C.; Kapnissi‐Christodoulou, Constantina P. (2014)
      The aim of the present study is the CE performance evaluation for the separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. In particular, the separation of indoprofen, carprofen, ketoprofen, ibuprofen, ...

    • Article  

      Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice 

      Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)
      Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

    • Article  

      Investigations on the surface properties of pure and alkali or alkaline earth metal doped ceria 

      Pashalidis, Ioannis; Theocharis, Charis R. (2000)
      The effect of parameters, such as initial cerium concentration and alkali or alkaline earth concentration in the reactant solution on the properties of precipitated ceria, have been investigated by nitrogen adsorption ...

    • Article  

      A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines 

      Chen, Y.; Liu, X.; Pisha, E.; Constantinou, Andreas I.; Hua, Y.; Shen, L.; Van Breemen, R. B.; Elguindi, E. C.; Blond, S. Y.; Zhang, Fengwangdong; Bolton, J. L. (2000)
      Estrogen replacement therapy has been correlated with an increased risk of developing breast or endometrial cancer. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin which is a minor component of the estrogen ...

    • Article  

      Molecular factors affecting the complex formation between deferiprone (L1) and Cu(II): Possible implications on efficacy and toxicity 

      Pashalidis, Ioannis; Kontoghiorghes, G. J. (2001)
      Deferiprone (1,2-dimethyl-3-hydroxypyrid-4-one, L1, CAS 30652-11-0) is a new chelating drug used worldwide for the treatment of iron overloading conditions. Spectrophotometric and potentiometric measurements were carried ...

    • Article  

      Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures 

      Gorham, R. D.; Forest, D. L.; Tamamis, Phanourios; López de Victoria, A.; Kraszni, M.; Kieslich, C. A.; Banna, C. D.; Bellows-Peterson, M. L.; Larive, C. K.; Floudas, C. A.; Archontis, Georgios Z.; Johnson, L. V.; Morikis, D. (2013)
      We have used a novel human retinal pigmented epithelial (RPE) cell-based model that mimics drusen biogenesis and the pathobiology of age-related macular degeneration to evaluate the efficacy of newly designed peptide ...

    • Article  

      The phenol steam reforming reaction over MgO-based supported Rh catalysts 

      Polychronopoulou, Kyriaki; Fierro, José Luis García; Efstathiou, Angelos M. (2004)
      The phenol steam reforming reaction toward H2 formation has been investigated in the 575-730°C range over MgO, CeO2, and ZrO 2 single metal oxides and various mixed metal oxides such as Mg-Ce-O, Mg-Zr-O, and Mg-Ce-Zr-O, ...

    • Article  

      Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1α-hydroxyvitamin D5 

      Mehta, R. G.; Moriarty, R. M.; Mehta, R. R.; Penmasta, R.; Lazzaro, G.; Constantinou, Andreas I.; Guo, L. (1997)
      Background: The form of vitamin D (vitamin D3) in fortified milk and the provitamin D produced by the body undergo metabolic activation to a biologically active form, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. This compound ...

    • Article  

      Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells 

      Tonetti, D. A.; Rubenstein, R.; DeLeon, M.; Zhao, H.; Pappas, S. G.; Bentrem, D. J.; Chen, B.; Constantinou, Andreas I.; Jordan, V. C. (2003)
      We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...

    • Article  

      Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...

    • Article  

      Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines 

      Parmenopoulou, Vanessa; Kantsadi, Anastassia L.; Tsirkone, Vicky G.; Chatzileontiadou, Demetra S. M.; Manta, Stella; Zographos, Spyros E.; Molfeta, Christina; Archontis, Georgios Z.; Agius, Loranne; Hayes, Joseph M.; Leonidas, Demetres D.; Komiotis, Dimitris (2014)
      Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 N-acyl-β-d-glucopyranosylamines ...

    • Article  

      Study on single crystal structure of the antimony(III) bromide complex with 3-methyl-2-mercaptobenzothiazole and biological activity of some antimony(III) bromide complexes with thioamides 

      Ozturk, I. I.; Metsios, A. K.; Filimonova-Orlova, S.; Kourkoumelis, Nikolaos; Hadjikakou, Sotiris K.; Manos, Manolis J.; Tasiopoulos, Anastasios J.; Karkabounas, Spyridon Ch; Milaeva, E. R.; Hadjiliadis, Nick (2012)
      Crystals of the [SbBr3(MMBZT)2] (1) complex (MMBZT = N-methyl-2- mercaptobenzothiazole) were grown from acetonitrile/methanol of the filtrate derived from the reaction between 3-methyl-2-mercaptobenzo thiazole (MMBZT) in ...

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