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Browsing by Subject "embryo"

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    • Article  

      1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study 

      Charalambous, Anna; Koyioni, Maria; Antoniades, Ioanna; Pegeioti, Despoina; Eleftheriou, Iro; Michaelidou, Sophia S.; Amelichev, Stanislav A.; Konstantinova, L. S.; Rakitin, O. A.; Koutentis, Panayiotis Andreas; Skourides, Paris A. (2015)
      A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline ...

    • Article  

      40LoVe and Samba are involved in Xenopusneural development and functionally distinct from hnRNP AB 

      Andreou, Maria I.; Yan, C. Y. I.; Skourides, Paris A. (2014)
      Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a large group of modular RNA-binding proteins classified according to their conserved domains. This modular nature, coupled with a large choice of alternative ...

    • Article  

      A ligand-independent integrin β1 mechanosensory complex guides spindle orientation 

      Petridou, Nicoletta I.; Skourides, Paris A. (2016)
      Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...

    • Article  

      Activation of endogenous FAK via expression of its amino terminal domain in xenopus embryos 

      Petridou, Nicoletta I.; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel S.; Guan, Junlin; Skourides, Paris A. (2012)
      Background: The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number of cellular processes including cell adhesion and migration. It has also been shown to play important roles during embryonic ...

    • Article  

      Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells 

      Antoniades, Ioanna; Stylianou, Panayiota; Christodoulou, Neophytos; Skourides, Paris A. (2017)
      We previously identified focal adhesion kinase (FAK) as an important regulator of ciliogenesis in multiciliated cells. FAK and other focal adhesion (FA) proteins associate with the basal bodies and their striated rootlets ...

    • Article  

      Calpain2 protease: A new member of the Wnt/Ca2+ pathway modulating convergent extension movements in Xenopus 

      Zanardelli, Sara; Christodoulou, Neophytos; Skourides, Paris A. (2013)
      Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate several physiological processes by limited cleavage of different substrates. The role of Calpain2 in embryogenesis is not clear with ...

    • Article  

      Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development 

      Georgiades, Pantelis; Kieszkiewicz, J.; Rozycka, M.; Brickell, P. M.; Lund, T. (1996)
      The major histocompatibility complex (MHC) class II-like molecules, H2-M, have an essential role in processing and presentation of antigens by the MHC class II molecules, because functional inactivation of these genes lead ...

    • Article  

      Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes 

      Iacovides, D.; Rizki, G.; Lapathitis, Georgios; Strati, K. (2016)
      The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...

    • Article  

      A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis 

      Petridou, Nicoletta I.; Stylianou, Panayiota; Skourides, Paris A. (2013)
      FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...

    • Article  

      Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila 

      Ligoxygakis, P.; Bray, S. J.; Apidianakis, Yiorgos; Delidakis, Christos (1999)
      A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors. ...

    • Article  

      Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development 

      Georgiades, Pantelis; Rossant, J. (2006)
      Although the trophoblast is necessary for the growth, viability and patterning of the mammalian embryo, understanding of its patterning role is still rudimentary. Expression of the transcription factor Ets2 is restricted ...

    • Article  

      Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation 

      Polydorou, Christiana; Georgiades, Pantelis (2013)
      Although extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive ...

    • Article  

      FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases 

      Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, Savvas N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. (2009)
      Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating ...

    • Article  

      High-resolution whole-mount in situ hybridization using quantum dot nanocrystals 

      Ioannou, Androulla; Eleftheriou, Iro; Lubatti, Andrea; Charalambous, Anna; Skourides, Paris A. (2012)
      The photostability and narrow emission spectra of nanometer-scale semiconductor crystallites (QDs) make them desirable candidates for whole-mount fluorescent in situ hybridization to detect mRNA transcripts in morphologically ...

    • Article  

      Imaging morphogenesis, in Xenopus with Quantum Dot nanocrystals 

      Stylianou, Panayiota; Skourides, Paris A. (2009)
      Mesoderm migration is a well studied morphogenetic movement that takes place during Xenopus gastrulation. The study of mesoderm migration and other morphogenetic movements has been primarily based on in vitro assays due ...

    • Article  

      The Ink4/Arf locus is a barrier for iPS cell reprogramming 

      Li, H.; Collado, M.; Villasante, A.; Strati, K.; Ortega, S.; Cãamero, M.; Blasco, M. A.; Serrano, M. (2009)
      The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also known as Pou5f1), Klf4 and Sox2 remain poorly understood. The ...

    • Article  

      Intein-mediated site-specific conjugation of Quantum Dots to proteins in vivo 

      Charalambous, Anna; Andreou, Maria I.; Skourides, Paris A. (2009)
      We describe an intein based method to site-specifically conjugate Quantum Dots (QDs) to target proteins in vivo. This approach allows the covalent conjugation of any nanostructure and/or nanodevice to any protein and thus ...

    • Article  

      KIF2β, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation 

      Santama, Niovi; Krijnse-Ĺocker, J.; Griffiths, G.; Noda, Y.; Hirokawa, N.; Dotti, C. G. (1998)
      Lysosomes concentrate juxtanuclearly in the region around the microtubule-organizing center by interaction with microtubules. Different experimental and physiological conditions can induce these organelles to move to the ...

    • Article  

      Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton 

      Antoniades, Ioanna; Stylianou, Panayiota; Skourides, Paris A. (2014)
      Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton ...

    • Article  

      The mouse Foxi3 transcription factor is necessary for the development of posterior placodes 

      Birol, O.; Ohyama, T.; Edlund, R. K.; Drakou, Katerina; Georgiades, Pantelis; Groves, A. K. (2016)
      The inner ear develops from the otic placode, one of the cranial placodes that arise from a region of ectoderm adjacent to the anterior neural plate called the pre-placodal domain. We have identified a Forkhead family ...

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