Browsing by Subject "neoplasm"

Article

Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy?

Constantinou, Constantina; Papas, Konstantinos A.; Constantinou, Andreas I. (2009)

In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ...

Article

Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model

Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)

Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...

Article

Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies

Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)

Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...

Article

Drosophila and the hallmarks of cancer

Christofi, T.; Apidianakis, Yiorgos (2013)

: Cancer was the disease of the twentieth century. Today it is still a leading cause of death worldwide despite being intensively investigated. Abundant knowledge exists regarding the pathological and molecular mechanisms ...

Article

Evolution of osmotic pressure in solid tumors

Voutouri, C.; Stylianopoulos, T. (2014)

The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...

Article

Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy

Voutouri, C.; Polydorou, C.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2016)

Despite the important role that mechanical forces play in tumor growth and therapy, the contribution of swelling to tumor mechanopathology remains unexplored. Tumors rich in hyaluronan exhibit a highly negative fixed charge ...

Article

Interactions of hydroxycarbamide (Hydroxyurea) with Iron and copper: Implications on toxicity and therapeutic strategies

Konstantinou, E.; Pashalidis, Ioannis; Kolnagou, A.; Kontoghiorghes, G. J. (2011)

Presented at the 19th International Conference on Chelation, London, UK, 13-16 November 2009Preliminary spectrophotometric and potentiometric studies have shown that hydroxycarbamide or hydroxyurea (HU) can interact with ...

Article

Model-based tumor growth dynamics and therapy response in a mouse model of de novo carcinogenesis

Loizides, Constantinos A.; Iacovides, D.; Hadjiandreou, M. M.; Rizki, G.; Achilleos, Achilleas P.; Strati, Katerina; Mitsis, Georgios D. (2015)

Tumorigenesis is a complex, multistep process that depends on numerous alterations within the cell and contribution from the surrounding stroma. The ability to model macroscopic tumor evolution with high fidelity may ...

Article

Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow

Wijeratne, P. A.; Hipwell, J. H.; Hawkes, D. J.; Stylianopoulos, T.; Vavourakis, V. (2017)

We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour–host environment. The model is specified to in-vitro data, facilitating biophysically realistic ...

Article

Multiscale modelling of solid tumour growth: the effect of collagen micromechanics

Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)

Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...

Article

Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer

Markou, P.; Apidianakis, Yiorgos (2014)

Article

Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites.

Christofi, T.; Apidianakis, Yiorgos (2013)

The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation, ...

Article

Role of vascular normalization in benefit from metronomic chemotherapy

Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)

Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...

Article

Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses

Iacovides, D.; Michael, S.; Achilleos, Charis; Strati, Katerina (2013)

A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...

Article

The Solid Mechanics of Cancer and Strategies for Improved Therapy

Stylianopoulos, T. (2017)

Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...

Article

Structural motifs and biological studies of new antimony(iii) iodide complexes with thiones

Ozturk, I.; Filimonova, S.; Hadjikakou, Sotiris K.; Kourkoumelis, Nikolaos; Dokorou, Vaso N.; Manos, Manolis J.; Tasiopoulos, Anastasios J.; Barsan, M. M.; Butler, I. S.; Milaeva, E. R.; Balzarini, J.; Hadjiliadis, Nick (2010)

Eight new antimony(III) iodide complexes of the heterocyclic thioamides, 2-mercapto-1-methylimidazole (MMI), 2-mercaptobenzlmidazole (MBZIM), 5-ethoxy-2-mercaptobenzimldazole (EtMBZIM), 2-mercaptothiazolidine (MTZD), ...

Article

Targeting Inflammation to Improve Tumor Drug Delivery

Gkretsi, V.; Zacharia, L. C.; Stylianopoulos, T. (2017)

Inefficient delivery of drugs is a main cause of chemotherapy failure in hypoperfused tumors. To enhance perfusion and drug delivery in these tumors, two strategies have been developed: vascular normalization, aiming at ...

Article

A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth

Vavourakis, V.; Wijeratne, P. A.; Shipley, R.; Loizidou, M.; Stylianopoulos, T.; Hawkes, D. J. (2017)

Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative ...