Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title

Now showing items 144-163 of 677

    • Article  

      The Dietary Anticancer Agent Ellagic Acid is a Potent Inhibitor of DNA Topoisomerases in Vitro 

      Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Moon, R.; Stoner, G. D.; Rao, K. (1995)
      Ellagic acid and 12 related agents have been tested for their ability to inhibit the activities of human DNA topoisomerase (topo) I and IL Using specific in vitro assays, we found ellagic acid and flavellagic acid to be ...
    • Article  

      Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis 

      Moon, R. C.; Constantinou, Andreas I. (1997)
      In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced ...
    • Article  

      Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer 

      Guo, J. -Y; Li, X.; Browning Jr., J. D.; Rottinghaus, G. E.; Lubahn, D. B.; Constantinou, Andreas I.; Bennink, M.; MacDonald, R. S. (2004)
      Consumption of soy foods has been weakly associated with reduced colon cancer risk. Colon cancer risk is influenced by estrogen exposure, although the mechanism through which this occurs is not defined. Conversion of ...
    • Article  

      Differential expression of molecular motors in the motor cortex of sporadic ALS 

      Pantelidou, M.; Zographos, Spyros E.; Lederer, C. W.; Kyriakides, Theodoros; Pfaffl, M. W.; Santama, Niovi (2007)
    • Article  

      Differential expression of the rat retinoid X receptor γ gene during skeletal muscle differentiation suggests a role in myogenesis 

      Georgiades, Pantelis; Brickell, P. M. (1997)
      Even though previous studies have shown that transcripts encoding the murine retinoid X receptor γ (RXRγ) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid ...
    • Article  

      Digenic inheritance and genetic modifiers 

      Deltas, C. (2018)
      Digenic inheritance (DI) concerns pathologies with the simplest form of multigenic etiology, implicating more than 1 gene (and perhaps the environment). True DI is when biallelic or even triallelic mutations in 2 distinct ...
    • Article  

      Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes 

      Iacovides, D.; Rizki, G.; Lapathitis, Georgios; Strati, Katerina (2016)
      The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...
    • Article  

      Discovery of old diseases: The molecular approach [1] 

      Constantinou-Deltas, Constantinos D. (2003)
    • Book  

      Diseases of renal parenchyma 

      Sahay, Manisha; Constantinou-Deltas, Constantinos D. (Intech, 2012)
    • Article  

      Disentangling the complexity of low complexity proteins 

      Mier, Pablo; Paladin, Lisanna; Tamana, Stella; Petrosian, Sophia; Hajdu-Soltész, Borbála; Urbanek, Annika; Gruca, Aleksandra; Plewczynski, Dariusz; Grynberg, Marcin; Bernadó, Pau; Gáspári, Zoltán; Ouzounis, Christos A.; Promponas, Vasilis J.; Kajava, Andrey V.; Hancock, John M.; Tosatto, Silvio C. E.; Dosztanyi, Zsuzsanna; Andrade-Navarro, Miguel A. (2020)
      AbstractThere are multiple definitions for low complexity regions (LCRs) in protein sequences, with all of them broadly considering LCRs as regions with fewer a
    • Article  

      DisProt: intrinsic protein disorder annotation in 2020 

      Hatos, András; Hajdu-Soltész, Borbála; Monzon, Alexander M.; Palopoli, Nicolas; Álvarez, Lucía; Aykac-Fas, Burcu; Bassot, Claudio; Benítez, Guillermo I.; Bevilacqua, Martina; Chasapi, Anastasia; Chemes, Lucia; Davey, Norman E.; Davidović, Radoslav; Dunker, A. Keith; Elofsson, Arne; Gobeill, Julien; Foutel, Nicolás S. González; Sudha, Govindarajan; Guharoy, Mainak; Horvath, Tamas; Iglesias, Valentin; Kajava, Andrey V.; Kovacs, Orsolya P.; Lamb, John; Lambrughi, Matteo; Lazar, Tamas; Leclercq, Jeremy Y.; Leonardi, Emanuela; Macedo-Ribeiro, Sandra; Macossay-Castillo, Mauricio; Maiani, Emiliano; Manso, José A.; Marino-Buslje, Cristina; Martínez-Pérez, Elizabeth; Mészáros, Bálint; Mičetić, Ivan; Minervini, Giovanni; Murvai, Nikoletta; Necci, Marco; Ouzounis, Christos A.; Pajkos, Mátyás; Paladin, Lisanna; Pancsa, Rita; Papaleo, Elena; Parisi, Gustavo; Pasche, Emilie; Barbosa Pereira, Pedro J.; Promponas, Vasilis J.; Pujols, Jordi; Quaglia, Federica; Ruch, Patrick; Salvatore, Marco; Schad, Eva; Szabo, Beata; Szaniszló, Tamás; Tamana, Stella; Tantos, Agnes; Veljkovic, Nevena; Ventura, Salvador; Vranken, Wim; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C. E.; Piovesan, Damiano (2020)
      The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version ...
    • Article  

      Distal renal tubular acidosis in a Libyan patient: Evidence for digenic inheritance 

      Nagara, Majdi; Papagregoriou, Gregory; Ben Abdallah, Rim; Landoulsi, Zied; Bouyacoub, Yosra; Elouej, Sahar; Kefi, Rym; Pippucci, Tommaso; Voskarides, Konstantinos; Bashamboo, Anu; McElreavey, Kenneth; Hachicha, Mongia; Romeo, Giovanni; Seri, Marco; Deltas, Constantinos; Abdelhak, Sonia (2018)
      Aim of the study Recent advances in understanding the underlying molecular mechanism for distal renal tubular acidosis (dRTA), led to an increased attention towards the primary and the familial forms of the disease. Mutations ...
    • Article  

      Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2 

      Kirmizis, Antonis; Santos-Rosa, H.; Penkett, C. J.; Singer, M. A.; Green, R. D.; Kouzarides, T. (2009)
      Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its ...
    • Article  

      Distribution and functions of kinectin isoforms 

      Santama, Niovi; Er, C. P. N.; Ong, L. -L; Yu, H. (2004)
    • Article  

      Distribution modelling of Eleonora's Falcon Falco eleonorae Géné, 1839 occurrence in its wintering grounds: A niche-based approach with satellite telemetry data 

      Kassara, Christina; Fric, Jakob; Sfenthourakis, Spyros (2014)
      Summary Eleonora's Falcon is a long-distance migrant of the Palearctic region. In recent years, the advent of satellite telemetry has enabled a more detailed investigation of the species's migratory and wintering periods. ...
    • Article  

      Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues 

      Mehta, R. G.; Mehta, R. R.; Constantinou, Andreas I.; Moon, R. C. (1995)
      Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...
    • Article  

      Diversification within an oceanic Mediterranean island: Insights from a terrestrial isopod 

      Dimitriou, Andreas C.; Antoniou, Aglaia; Alexiou, Ioannis; Poulakakis, Nikos; Parmakelis, Aristeidis; Sfenthourakis, Spyros (ScienceDirect, 2022-07-08)
      Understanding intra-island patterns of evolutionary divergence, including cases of cryptic diversity, is a crucial step towards deciphering speciation processes. Cyprus is an oceanic island isolated for at least 5.3 Mya ...
    • Article  

      DNA barcoding of bird species in Cyprus: a tool for conservation purposes 

      Dimitriou, Andreas C.; Forcina, Giovanni; Papazoglou, Clairie; Panayides, Panicos; Guerrini, Monica; Crabtree, Alan; Barbanera, Filippo; Sfenthourakis, Spyros (2017)
      DNA barcoding has become a widely used and valuable tool in taxonomic research during the past three decades and its application is expanding to fields such as wildlife forensics (e.g. anti-poaching actions). One of the ...
    • Article  

      DNA variant databases improve test accuracy and phenotype prediction in Alport syndrome 

      Savige, J.; Ars, E.; Cotton, R. G. H.; Crockett, D.; Dagher, H.; Constantinou-Deltas, Constantinos D.; Ding, J.; Flinter, F.; Pont-Kingdon, G.; Smaoui, N.; Torra, R.; Storey, H. (2014)
      X-linked Alport syndrome is a form of progressive renal failure caused by pathogenic variants in the COL4A5 gene. More than 700 variants have been described and a further 400 are estimated to be known to individual ...
    • Article  

      Does by-catch pose a threat for the conservation of seabird populations in the southern ionian sea (eastern Mediterranean)? A questionnaire-based survey of local fisheries 

      Karris, Georgios; Fric, Jakob; Kitsou, Z.; Kalfopoulou, J.; Giokas, Sinos; Sfenthourakis, Spyros; Poirazidis, K. (2013)
      A significant number of studies worldwide have shown that incidental catches (by-catch) of seabirds in fishing gear might pose a considerable risk for the conservation of their populations. Nevertheless, reliable data on ...