Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title

Now showing items 256-275 of 677

    • Article  

      Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells 

      Constantinou, Andreas I.; Kamath, N.; Murley, J. S. (1998)
      The aim of this study was to identify the molecular mechanism of action of the isoflavone, genistein. Genistein at 0.15 mM caused MCF-7 apoptotic cell death, which was accompanied by cell cycle delay in the G2/M phase. ...
    • Article  

      Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells 

      Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)
      The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells
    • Article  

      Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice 

      Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)
      Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...
    • Article  

      Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells 

      Kiguchi, K.; Constantinou, Andreas I.; Huberman, E. (1990)
    • Article  

      Genomic approaches that aid in the identification of transcription factor target genes 

      Kirmizis, Antonis; Farnham, P. J. (2004)
      It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...
    • Article  

      Genomic data reveal deep genetic structure but no support for current taxonomic designation in a grasshopper species complex 

      Tonzo, Vanina; Papadopoulou, Anna; Ortego, Joaquín (2019)
      Taxonomy has traditionally relied on morphological and ecological traits to interpret and classify biological diversity. Over the last decade, technological advances and conceptual developments in the field of molecular ...
    • Book  

      Genomic Elements in Health, Disease and Evolution : Junk DNA 

      Felekkis, Kyriacos N.; Voskarides, Konstantinos (Springer New York, 2015)
    • Article  

      Genotype-phenotype correlation in X-linked Alport syndrome patients carrying missense mutations in the collagenous domain of COL4A5 

      Tsiakkis, D.; Pieri, Myrtani; Koupepidou, P.; Demosthenous, Panayiota; Panayidou, K.; Constantinou-Deltas, Constantinos D. (2012)
    • Article  

      Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease 

      Magistroni, R.; He, N.; Wang, K.; Andrew, R.; Johnson, A.; Gabow, P.; Dicks, E.; Parfrey, P.; Torra, R.; San-Millan, J. L.; Coto, E.; Van Dijk, M.; Breuning, M.; Peters, D.; Bogdanova, N.; Ligabue, G.; Albertazzi, A.; Hateboer, N.; Demetriou, Kyproula; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D.; St. George-Hyslop, P.; Ravine, D.; Pei, Y. (2003)
      Autosomal dominant polycystic kidney disease (ADPKD) is a common Mendelian disorder that affects approximately 1 in 1000 live births. Mutations of two genes, PKD1 and PKD2, account for the disease in approximately 80 to ...
    • Article  

      Genotyping HIV-1 and HCV strains by a combinatorial DNA melting assay (COMA) 

      Kostrikis, Leontios G.; Shin, S.; Ho, David D. (1998)
      Background: Human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) strains can be genetically classified into genetic lineages known as genetic types of subtypes according to phylogenetic analyses of ...
    • Article  

      The genus Ligidium Brandt (Isopoda, Oniscidea) in Greece. Taxonomy and distribution 

      Sfenthourakis, Spyros (1993)
    • Article  

      Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease 

      Koptides, Michael; Hadjimichael, C.; Koupepidou, P.; Pierides, Alkis M.; Constantinou-Deltas, Constantinos D. (1999)
      Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in one of three genes: PKD1 on chromosome 16 accounts for ~85% of cases whereas PKD2 on chromosome 4 accounts for ~15%. Mutations in the PKD3 gene ...
    • Article  

      Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis 

      Hemelaar, Joris; Elangovan, Ramyiadarsini; Yun, Jason; Dickson-Tetteh, Leslie; Fleminger, Isabella; Kirtley, Shona; Williams, Brian; Gouws-Williams, Eleanor; Ghys, Peter D; Abimiku, Alash'le G; Agwale, Simon; Archibald, Chris; Avidor, Boaz; Barbás, María Gabriela; Barre-Sinoussi, Francoise; Barugahare, Banson; Belabbes, El Hadj; Bertagnolio, Silvia; Birx, Deborah; Bobkov, Aleksei F; Brandful, James; Bredell, Helba; Brennan, Catherine A; Brooks, James; Bruckova, Marie; Buonaguro, Luigi; Buonaguro, Franco; Buttò, Stefano; Buve, Anne; Campbell, Mary; Carr, Jean; Carrera, Alex; Carrillo, Manuel Gómez; Celum, Connie; Chaplin, Beth; Charles, Macarthur; Chatzidimitriou, Dimitrios; Chen, Zhiwei; Chijiwa, Katsumi; Cooper, David; Cunningham, Philip; Dagnra, Anoumou; de Gascun, Cillian F; Del Amo, Julia; Delgado, Elena; Dietrich, Ursula; Dwyer, Dominic; Ellenberger, Dennis; Ensoli, Barbara; Essex, Max; Gao, Feng; Fleury, Herve; Fonjungo, Peter N; Foulongne, Vincent; Gadkari, Deepak A; García, Federico; Garsia, Roger; Gershy-Damet, Guy Michel; Glynn, Judith R; Goodall, Ruth; Grossman, Zehava; Lindenmeyer-Guimarães, Monick; Hahn, Beatrice; Hamers, Raph L; Hamouda, Osamah; Handema, Ray; He, Xiang; Herbeck, Joshua; Ho, David D; Holguin, Africa; Hosseinipour, Mina; Hunt, Gillian; Ito, Masahiko; Bel Hadj Kacem, Mohamed Ali; Kahle, Erin; Kaleebu, Pontiano Kaleebu; Kalish, Marcia; Kamarulzaman, Adeeba; Kang, Chun; Kanki, Phyllis; Karamov, Edward; Karasi, Jean-Claude; Kayitenkore, Kayitesi; Kelleher, Tony; Kitayaporn, Dwip; Kostrikis, Leondios G.; Kucherer, Claudia; Lara, Claudia; Leitner, Thomas; Liitsola, Kirsi; Lingappa, Jai; Linka, Marek; Lorenzana de Rivera, Ivette; Lukashov, Vladimir; Maayan, Shlomo; Mayr, Luzia; McCutchan, Francine; Meda, Nicolas; Menu, Elisabeth; Mhalu, Fred; Mloka, Doreen; Mokili, John L; Montes, Brigitte; Mor, Orna; Morgado, Mariza; Mosha, Fausta; Moussi, Awatef; Mullins, James; Najera, Rafael; Nasr, Mejda; Ndembi, Nicaise; Neilson, Joel R; Nerurkar, Vivek R; Neuhann, Florian; Nolte, Claudine; Novitsky, Vlad; Nyambi, Philippe; Ofner, Marianna; Paladin, Fem J; Papa, Anna; Pape, Jean; Parkin, Neil; Parry, Chris; Peeters, Martine; Pelletier, Alexandra; Pérez-Álvarez, Lucía; Pillay, Deenan; Pinto, Angie; Quang, Trinh Duy; Rademeyer, Cecilia; Raikanikoda, Filimone; Rayfield, Mark A; Reynes, Jean-Marc; Rinke de Wit, Tobias; Robbins, Kenneth E; Rolland, Morgane; Rousseau, Christine; Salazar-Gonzales, Jesus; Salem, Hanan; Salminen, Mika; Salomon, Horacio; Sandstrom, Paul; Santiago, Mario L; Sarr, Abdoulaye D; Schroeder, Bryan; Segondy, Michel; Selhorst, Philippe; Sempala, Sylvester; Servais, Jean; Shaik, Ansari; Shao, Yiming; Slim, Amine; Soares, Marcelo A; Songok, Elijah; Stewart, Debbie; Stokes, Julie; Subbarao, Shambavi; Sutthent, Ruengpung; Takehisa, Jun; Tanuri, Amilcar; Tee, Kok Keng; Thapa, Kiran; Thomson, Michael; Tran, Tyna; Urassa, Willy; Ushijima, Hiroshi; van de Perre, Philippe; van der Groen, Guido; van Laethem, Kristel; van Oosterhout, Joep; van Sighem, Ard; van Wijngaerden, Eric; Vandamme, Anne-Mieke; Vercauteren, Jurgen; Vidal, Nicole; Wallace, Lesley; Williamson, Carolyn; Wolday, Dawit; Xu, Jianqing; Yang, Chunfu; Zhang, Linqi; Zhang, Rong (2019)
      Background Global genetic diversity of HIV-1 is a major challenge to the development of HIV vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and recombinants during 1990–2015. Methods ...
    • Article  

      Global dispersal pattern of HIV type 1 subtype CRF01-AE: A genetic trace of human mobility related to heterosexual sexual activities centralized in southeast Asia 

      Angelis, Konstantinos; Albert, Jan; Mamais, Ioannis A.; Magiorkinis, Gkikas; Hatzakis, Angelos E.; Hamouda, O.; Struck, D.; Vercauteren, J.; Wensing, A. M. J.; Alexiev, Ivailo; Åsjö, Birgitta; Balotta, Claudia; Camacho, Ricardo J.; Coughlan, S.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kostrikis, Leontios G.; Lepej, S.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Schmit, J. -C; Sönnerborg, A.; Staneková, D.; Stanojevic, M.; Boucher, C. A. B.; Kaplan, L.; Vandamme, A. -M; Paraskevis, Dimitrios N. (2015)
      Background. Human immunodeficiency virus type 1 (HIV-1) subtype CRF01-AE originated in Africa and then passed to Thailand, where it established a major epidemic. Despite the global presence of CRF01-AE, little is known ...
    • Article  

      Global Dispersal Pattern of HIV Type 1 Subtype CRF01_AE: A Genetic Trace of Human Mobility Related to Heterosexual Sexual Activities Centralized in Southeast Asia 

      Angelis, Konstantinos; Albert, Jan; Mamais, Ioannis A.; Magiorkinis, Gkikas; Hatzakis, Angelos E.; Hamouda, Osamah; Struck, Daniel; Vercauteren, Jurgen; Wensing, Annemarie M. J.; Alexiev, Ivailo; Åsjö, Birgitta; Balotta, Claudia; Camacho, Ricardo J.; Coughlan, Suzie; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kostrikis, Leontios G.; Lepej, Snjezana; Liitsola, Kirsi; Linka, Marek; Nielsen, Claus; Otelea, Dan; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Schmit, Jean-Claude; Sönnerborg, Anders; Staneková, Danica; Stanojevic, Maja; Boucher, Charles A. B.; Kaplan, Lauren; Vandamme, Anne-Mieke; Paraskevis, Dimitrios N. (2014)
    • Article  

      Global distribution of the CCR2-641/CCR5-59653T HIV-1 disease-protective haplotype 

      Martinson, J. J.; Hong, L.; Karanicolas, R.; Moore, J. P.; Kostrikis, Leontios G. (2000)
      Objectives: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. The CCR2-641 genetic variant [a G to A substitution resulting in a valine (V) to ...
    • Article  

      Global genetic variation of HIV-1 infection 

      Anastassopoulou, C. G.; Kostrikis, Leontios G. (2006)
      Variability, both at the population (interhost) as well as at the individual (intrahost) level is a key property of HIV that stems mainly from the inherent infidelity of the reverse transcriptase enzyme that the virus uses ...
    • Article  

      The global spread of HIV-1 subtype B epidemic 

      Magiorkinis, Gkikas; Angelis, Konstantinos; Mamais, Ioannis A.; Katzourakis, A.; Hatzakis, Angelos E.; Albert, Jan; Lawyer, G.; Hamouda, O.; Struck, D.; Vercauteren, J.; Wensing, A.; Alexiev, Ivailo; Åsjö, Birgitta; Balotta, Claudia; Gomes, P.; Camacho, Ricardo J.; Coughlan, S.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kostrikis, Leontios G.; Lepej, S. J.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Schmit, J. C.; Sönnerborg, A.; Staneková, D.; Stanojevic, M.; Stylianou, Dora C.; Boucher, C. A. B.; Nikolopoulos, Georgios K.; Vasylyeva, T.; Friedman, S. R.; van de Vijver, D.; Angarano, G.; Chaix, M. -L; de Luca, A.; Korn, K.; Loveday, C.; Soriano, V.; Yerly, S.; Zazzi, M.; Vandamme, A. M.; Paraskevis, Dimitrios N. (2016)
      Human immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B ...
    • Article  

      Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch 

      Apidianakis, Yiorgos; Grbavec, D.; Stifani, S.; Delidakis, Christos (2001)
      Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...
    • Book  

      Ground Beetles (Carabidae) of Greece 

      Sfenthourakis, Spyros (Pensoft Publishers, 2011)
      Ground beetles (Carabidae, including tiger beetles, paussid beetles and bombardier beetles) are one of the most diverse insect families in Europe. They occur in apparently all terrestrial habitats and represent a major ...