Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title
Now showing items 528-547 of 677
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Regulation of Lactate Dehydrogenase Gene Expression by AMP‐dependent Protein Kinase Subunits
(1986)
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Regulation of retinoid X receptor-γ gene transcript levels in rat heart cells
(1998)Retinoid X receptor-γ (RXRγ) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life. However, its expression in embryonic and neonatal heart has not been investigated ...
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Renal graft outcome in autosomal dominant medullary cystic kidney disease type 1
(2013)Background: Medullary cystic kidney disease (MCKD) is an inherited interstitial nephritis, leading to endstage renal disease (ESRD) between the fourth and seventh decade of life. MCKD shares clinical and morphological ...
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Article
Resistance to etoposide in human leukemia HL-60 cells: Reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides
(1996)Tumor cell resistance to anthracyclines and epipodophyllotoxins can be due to reduced drug accumulation and/or alterations in the activity of topoisomerase II (TOPO II). HL-60 cells selected in 0.05 μg/ml doxorubicin (DOX) ...
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Response of the temperate scleractinian coral Cladocora caespitosa to high temperature and long-term nutrient enrichment
(2019)Anthropogenic nutrient enrichment and increased seawater temperatures are responsible for coral reef decline. In particular, they disrupt the relationship between corals and their dinoflagellate symbionts (bleaching). ...
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Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe
(2018)All-oral direct-acting antiviral drugs (DAAs) for hepatitis C virus, which have response rates of 95% or more, represent a major clinical advance. However, the high list price of DAAs has led many governments to restrict ...
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RET proto-oncogene mutations are restricted to codon 618 in Cypriot families with multiple endocrine neoplasia 2
(2011)Background: RET germline mutations predispose to the development of inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN2). Several variants of the RET proto-oncogene including G691S and S904S have been ...
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Retinoid X receptor-γ gene expression is developmentally regulated in the embryonic rodent peripheral nervous system
(1998)The retinoid X receptor-γ (RXRγ) is a transcription factor that belongs to the thyroid hormone/retinoid family of nuclear receptors. Previous studies have shown that RXRγ is expressed in the developing peripheral nervous ...
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Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance
(2013)The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen resistance (MCF-7/TAM-R) and this ...
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A review of phylogeographic analyses of animal taxa from the aegean and surrounding regions
(2015)We provide a review and synthesis of key findings in phylogeographic research on terrestrial animals in the Aegean archipelago (Greece) and surrounding regions (Greek mainland, southern Balkans and Asia Minor). A critical ...
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Revisiting the saproxylic beetle ‘Propomacrus cypriacus Alexis & Makris, 2002’ (Coleoptera: Euchiridae) using molecular, morphological and ecological data
(2017)Propomacrus cypriacus a saproxylic beetle endemic to Cyprus, was described as a species distinct from P. bimucronatus on the basis of a few morphological characters and has been evaluated as Critically Endangered by IUCN, ...
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RNA intereference: A powerful laboratory tool and its therapeutic implications
(2006)Ever since RNA intereference (RNAi) was discovered in the early 1990s, a number of scientists from the academic and biotechnology world have continued to view it as the revolutionary discovery of the century. Unequivocally, ...
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Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis
(2006)Notch is the receptor in a signalling pathway that operates in a diverse spectrum of developmental processes. Its ligands (e.g. Serrate) are transmembrane proteins whose signalling competence is regulated by the ...
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The role of ecological specialization in shaping patterns of insular communities
(Wiley, 2020-09-30)Aim: Research on the response of species richness to area and environmental heterogeneity so far has not addressed possible effects of species’ differences in ecological specialization. Herein we provide a new metric, ...
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The role of molecular genetics in diagnosing familial hematuria(s)
(2012)Familial microscopic hematuria (MH) of glomer-ular origin represents a heterogeneous group of monogenic conditions involving several genes, some of which remain unknown. Recent advances have increased our understanding and ...
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Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer
(2007)Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). ...
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Roles for genomic imprinting and the zygotic genome in placental development
(2001)The placenta contains several types of fetomaternal interfaces where zygote-derived cells interact with maternal cells or maternal blood for the promotion of fetal growth and viability. The genetic factors regulating the ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase
(1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis
(1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Article