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Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats
(2003)
The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary organ culture (MMOC) model. ...
Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity
(2000)
The present study was undertaken to determine if in vitro inhibition of one or both of the two most dominant mammalian DNA topoisomerases (topos) is common among chemopreventive agents. To determine if an agent was a topo ...
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis
(2006)
Notch is the receptor in a signalling pathway that operates in a diverse spectrum of developmental processes. Its ligands (e.g. Serrate) are transmembrane proteins whose signalling competence is regulated by the ...
T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy
(2001)
Objective: To determine whether improved prediction of AIDS-free survival following HIV-1 seroconversion is achieved by measuring HIV-1 2-LTR episomal DNA (2-LTR) circles and T cell receptor rearrangement excision circles ...
Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs
(2008)
Current observations in the literature suggest that vitamin E may be a suitable candidate for the adjuvant treatment of cancer. Even though historically most research focused on α-tocopherol, more recent evidence suggests ...
vavCre transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages
(2002)
Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic ...
Comparative developmental anatomy of the murine and human definitive placentae
(2002)
The placenta of eutherian mammals is a remarkable biological structure. It is composed of both zygote-derived and maternal cells, and mediates the complex interactions between the mother and the fetus that are necessary ...
Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12
(2000)
Genetic analysis has shown that the distal portion of mouse chromosome 12 is imprinted
Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development
(2006)
Although the trophoblast is necessary for the growth, viability and patterning of the mammalian embryo, understanding of its patterning role is still rudimentary. Expression of the transcription factor Ets2 is restricted ...
Roles for genomic imprinting and the zygotic genome in placental development
(2001)
The placenta contains several types of fetomaternal interfaces where zygote-derived cells interact with maternal cells or maternal blood for the promotion of fetal growth and viability. The genetic factors regulating the ...