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Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27Kip1-dependent G1/S cell cycle arrest in conjunction with NF-κB activation
(2009)
2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain ...
Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon cancer cells
(1998)
We hypothesized that unexplained increases in nucleoside triphosphates (NTP) observed by 31P magnetic resonance spectroscopy (MRS) after treatment of tumours by DNA-damaging agents were related to chemotherapy-induced ...
The unknown caspase: The role of caspase-14 in cell death and disease
(Nova Science Publishers, Inc., 2016)
Caspase-14 is unique among caspase family proteases. It is the shortest member of the caspase family that was first described as a developmentally regulated protease due to its high expression in embryonic tissues. Based ...
Breast Cancer Epigenetics
(Elsevier Inc., 2015)
The molecular mechanisms underlying the development and progression of breast cancer are far from being understood. It is obvious that the initiation of breast cancer as well as its transition toward distinct breast cancer ...