Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences: Recent submissions
Now showing items 401-420 of 677
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Loss of heterozygosity in polycystic kidney disease with a missense mutation in the repeated region of PKD1
(1998)Loss of heterozygosity (LOH) is a molecular phenomenon that denotes the loss of one of the two alleles at a specific locus. It is frequently associated with tumour suppressor genes in various cancers and also with ...
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Autosomal dominant polycystic kidney disease: Molecular genetics and molecular pathogenesis
(2000)Mutations in three different genes, PKD1, PKD2 and PKD3, can cause a very similar clinical picture of the autosomal dominant form of polycystic kidney disease (ADPKD). Apparently, mutations in the PKD3 gene, which is still ...
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Novel NPR1 polymorphic variants and its exclusion as a candidate gene for medullary cystic kidney disease (ADMCKD) type 1
(2001)Autosomal dominant medullary cystic kidney disease (ADMCKD) is an adult-onset heterogeneous genetic nephropathy characterized by salt wasting and end-stage renal failure. The gene responsible for ADMCKD-1 was mapped on ...
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Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease
(2000)Polycystic kidney disease (ADPKD) is a condition with an autosomal dominant mode of inheritance and adult onset. Two forms of the disease, ADPKD1 and ADPKD2, caused by mutations in PKD1 and PKD2, respectively, are very ...
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Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease
(1999)Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in one of three genes: PKD1 on chromosome 16 accounts for ~85% of cases whereas PKD2 on chromosome 4 accounts for ~15%. Mutations in the PKD3 gene ...
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Testing alternative hypotheses for evolutionary diversification in an african songbird: Rainforest refugia versus ecological gradients
(2011)Geographic isolation in rainforest refugia and local adaptation to ecological gradients may both be important drivers of evolutionary diversification. However, their relative importance and the underlying mechanisms of ...
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The cypriot and Iranian National Mutation Frequency Databases.
(2006)The National Mutation Frequency Databases are continuously updated mutation depositories, which contain extensive information over the described genetic heterogeneity of an ethnic group or population. Here, we report the ...
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Birdsong tuned to the environment: Green hylia song varies with elevation, tree cover, and noise
(2009)Animals that communicate acoustically must compete for acoustic space in order to convey their signals effectively. Tropical rainforest birds live in an extremely diverse acoustic community consisting of other birds, ...
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Territorial dynamics of Mexican Ant-thrushes Formicarius moniliger revealed by individual recognition of their songs
(2011)The ability to monitor interactions between individuals over time can provide us with information on life histories, mating systems, behavioural interactions between individuals and ecological interactions with the ...
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Character displacement of song and morphology in African tinkerbirds
(2009)Divergence in acoustic signals between populations of animals can lead to species recognition failure, reproductive isolation, and speciation. Character displacement may facilitate coexistence of species in natural ...
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Novel courtship behavior in the Little Greenbul (Andropadus virens)
(2008)The Little Greenbul (Andropadus virens) is a common African forest bird that is thought to form monogamous pair bonds. In March 2007, I observed a male hanging below a presumed female perched on a branch, apparently ...
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Using songs to identify individual mexican antthrush formicarius moniliger: Comparison of four classification methods
(2009)This study compares the ability of four classification methods to distinguish between songs of individual Mexican Antthrush Formicarius moniliger: self-organizing maps (SOMs), discriminant function analysis, fuzzy logic ...
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Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
(2007)Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5′ end of active genes and contributes to ...
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Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
(2004)Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in ...
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Genomic approaches that aid in the identification of transcription factor target genes
(2004)It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...
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Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy
(2003)We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...
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Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
(2009)Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its ...