Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences: Recent submissions
Now showing items 521-540 of 677
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Article
RNA intereference: A powerful laboratory tool and its therapeutic implications
(2006)Ever since RNA intereference (RNAi) was discovered in the early 1990s, a number of scientists from the academic and biotechnology world have continued to view it as the revolutionary discovery of the century. Unequivocally, ...
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Book
Genomic Elements in Health, Disease and Evolution : Junk DNA
(Springer New York, 2015)
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Article
Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2
(2008)Background. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes ...
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Article
MicroRNAs: A newly described class of encoded molecules that play a role in health and disease
(2010)14(4): 236-240.
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Doctoral Thesis
The effect of noise on dynamics and the influence of biochemical systems
(Imperial College London, 2010)
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Article
CNVs-microRNAs interactions demonstrate unique characteristics in the human genome. An interspecies in silico analysis
(2013)MicroRNAs (miRNAs) and copy number variations (CNVs) represent two classes of newly discovered genomic elements that were shown to contribute to genome plasticity and evolution. Recent studies demonstrated that miRNAs and ...
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Article
Autosomal dominant tubulointerstitial kidney disease: Diagnosis, classification, and management - A KDIGO consensus report
(2015)Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been ...
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Article
Founder mutations in the ATP6V1B1 geneexplain most cypriot cases of distal renal tubular acidosis: First prenatal diagnosis
(2011)Aims: To investigate clinically and genetically all the distal renal tubular acidosis (dRTA) cases in Cyprus, to study one more family from Greece and to perform the first dRTA prenatal diagnosis. We also tried to find any ...
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Article
New phenotypic aspects of the decidual spiral artery wall during early post-implantation mouse pregnancy
(2011)During pregnancy the walls of decidual spiral arteries (SAs) undergo clinically important structural modifications crucial for embryo survival/growth and maternal health. However, the mechanisms of SA remodeling (SAR) are ...
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Article
A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis
(2013)Background: The unfolded protein response (UPR) is a major signalling cascade acting in the quality control of protein folding in the endoplasmic reticulum (ER). The cascade is known to play an accessory role in a range ...
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Doctoral Thesis
The effect of noise on dynamics and the influence of biochemical systems [electronic resource]
(Imperial College London, 2010)
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Book Chapter
Overview of Polymer and Copolymer Materials for Organic Photovoltaics
(Wiley Blackwell, 2014)
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Article
X-linked Alport syndrome in Hellenic families: Phenotypic heterogeneity and mutations near interruptions of the collagen domain in COL4A5
(2012)The X-linked Alport syndrome (ATS) is caused by mutations in COL4A5 and exhibits a widely variable expression. Usually ATS is heralded with continuous microhematuria which rapidly progresses to proteinuria, hypertension ...
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Article
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Article
DNA barcoding of bird species in Cyprus: a tool for conservation purposes
(2017)DNA barcoding has become a widely used and valuable tool in taxonomic research during the past three decades and its application is expanding to fields such as wildlife forensics (e.g. anti-poaching actions). One of the ...
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Article
A serum-free and defined medium for the culture of mammalian postimplantation embryos
(2015)Whole embryo culture (WEC) of postimplantation rodent embryos is widely used for the study of mammalian embryogenesis and developmental toxicity testing. Its major advantage is that it allows direct access to embryos for ...
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Article
Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe
(2010)Background HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe. Studies have demonstrated that HIV-1 DNA load in ...
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Article
In vivo imaging of quantum dots encapsulated in phospholipid micelles
(2002)Fluorescent semiconductor nanocrystals (quantum dots) have the potential to revolutionize biological imaging, but their use has been limited by difficulties in obtaining nanocrystals that are biocompatible. To address this ...
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Article
Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus
(2010)The most high-risk population for HCV transmission worldwide today are intravenous drug users. HCV genotypes in the general population in Cyprus demonstrate a polyphyletic infection and include subtypes associated with ...
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Article
Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development
(2008)The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates ...