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dc.contributor.authorBagos, Pantelis G.en
dc.contributor.authorKarnaouri, Anthi C.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorHamodrakas, Stavros J.en
dc.creatorBagos, Pantelis G.en
dc.creatorKarnaouri, Anthi C.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorHamodrakas, Stavros J.en
dc.date.accessioned2018-06-22T09:52:29Z
dc.date.available2018-06-22T09:52:29Z
dc.date.issued2007
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41374
dc.description.abstractWe conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies summarizing information about 3375 MS cases and 2930 healthy controls. Two polymorphisms were of interest: the exon 1 +49 A/G polymorphism (in 18 studies) and the promoter - 318 C/T polymorphism (in 10 studies). Using random-effects methods we found no evidence for association of the various contrasts of genotypes (or allele frequencies) with the disease. There was significant between-studies heterogeneity that could not be explained by the ethnicity of the populations studied or by other summary measures (gender, disease course, latitude). The major finding of the meta-analysis, apart from the lack of an overall association, consists of detecting a significant time trend of the OR for the contrast of GA versus GG +AA genotypes of the exon 1 +49 A/G polymorphism. In particular, using cumulative meta-analysis we found that the large number of conflicting results on the subject was triggered by the early appearance of a highly significant published result (a study that indicated a significant association of the genotype with the disease). © 2007 SAGE Publications.en
dc.language.isoengen
dc.sourceMultiple Sclerosisen
dc.subjectArticleen
dc.subjectGenderen
dc.subjectMeta-analysisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectDisease courseen
dc.subjectGenetic associationen
dc.subjectGene frequencyen
dc.subjectGenotypeen
dc.subjectPolymorphismen
dc.subjectRandom effectsen
dc.subjectAdenineen
dc.subjectAntigensen
dc.subjectCden
dc.subjectCtla-4en
dc.subjectCytosineen
dc.subjectCytotoxic t lymphocyte antigen 4en
dc.subjectDifferentiationen
dc.subjectEthnicityen
dc.subjectExonen
dc.subjectGeneticen
dc.subjectGenetic epidemiologyen
dc.subjectGenetic polymorphismen
dc.subjectGenetic predisposition to diseaseen
dc.subjectGuanineen
dc.subjectMultiple sclerosisen
dc.subjectPathogenesisen
dc.subjectPromoter regionen
dc.subjectRisk assessmenten
dc.subjectRisk factorsen
dc.subjectThymineen
dc.titleNo evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1177/1352458507078059
dc.description.volume13
dc.description.issue2
dc.description.startingpage156
dc.description.endingpage168
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]


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