No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysis
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Karnaouri, Anthi C. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Hamodrakas, Stavros J. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Karnaouri, Anthi C. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Hamodrakas, Stavros J. | en |
dc.date.accessioned | 2018-06-22T09:52:29Z | |
dc.date.available | 2018-06-22T09:52:29Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41374 | |
dc.description.abstract | We conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies summarizing information about 3375 MS cases and 2930 healthy controls. Two polymorphisms were of interest: the exon 1 +49 A/G polymorphism (in 18 studies) and the promoter - 318 C/T polymorphism (in 10 studies). Using random-effects methods we found no evidence for association of the various contrasts of genotypes (or allele frequencies) with the disease. There was significant between-studies heterogeneity that could not be explained by the ethnicity of the populations studied or by other summary measures (gender, disease course, latitude). The major finding of the meta-analysis, apart from the lack of an overall association, consists of detecting a significant time trend of the OR for the contrast of GA versus GG +AA genotypes of the exon 1 +49 A/G polymorphism. In particular, using cumulative meta-analysis we found that the large number of conflicting results on the subject was triggered by the early appearance of a highly significant published result (a study that indicated a significant association of the genotype with the disease). © 2007 SAGE Publications. | en |
dc.language.iso | eng | en |
dc.source | Multiple Sclerosis | en |
dc.subject | Article | en |
dc.subject | Gender | en |
dc.subject | Meta-analysis | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Disease course | en |
dc.subject | Genetic association | en |
dc.subject | Gene frequency | en |
dc.subject | Genotype | en |
dc.subject | Polymorphism | en |
dc.subject | Random effects | en |
dc.subject | Adenine | en |
dc.subject | Antigens | en |
dc.subject | Cd | en |
dc.subject | Ctla-4 | en |
dc.subject | Cytosine | en |
dc.subject | Cytotoxic t lymphocyte antigen 4 | en |
dc.subject | Differentiation | en |
dc.subject | Ethnicity | en |
dc.subject | Exon | en |
dc.subject | Genetic | en |
dc.subject | Genetic epidemiology | en |
dc.subject | Genetic polymorphism | en |
dc.subject | Genetic predisposition to disease | en |
dc.subject | Guanine | en |
dc.subject | Multiple sclerosis | en |
dc.subject | Pathogenesis | en |
dc.subject | Promoter region | en |
dc.subject | Risk assessment | en |
dc.subject | Risk factors | en |
dc.subject | Thymine | en |
dc.title | No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1177/1352458507078059 | |
dc.description.volume | 13 | |
dc.description.issue | 2 | |
dc.description.startingpage | 156 | |
dc.description.endingpage | 168 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.contributor.orcid | Karnaouri, Anthi C. [0000-0001-9164-7667] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |
dc.gnosis.orcid | 0000-0001-9164-7667 |
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