Prognosis of pregnancy-associated breast cancer: A meta-analysis of 30 studies
dc.contributor.author | Jr, H. A. Azim | en |
dc.contributor.author | Santoro, L. | en |
dc.contributor.author | Russell-Edu, W. | en |
dc.contributor.author | Pentheroudakis, George | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Peccatori, Fedro A. | en |
dc.creator | Jr, H. A. Azim | en |
dc.creator | Santoro, L. | en |
dc.creator | Russell-Edu, W. | en |
dc.creator | Pentheroudakis, George | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Peccatori, Fedro A. | en |
dc.date.accessioned | 2018-06-22T09:52:31Z | |
dc.date.available | 2018-06-22T09:52:31Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41392 | |
dc.description.abstract | Background: Pregnancy-associated breast cancer (PABC) is relatively rare with considerable controversy regarding its prognosis. Patients & methods: Two of the authors independently performed a literature search with no date or language restrictions. Eligible studies were control-matched, population-based and hospital-based studies that addressed the outcome of patients diagnosed during pregnancy or 1-year afterwards. The primary and secondary end-points were overall and disease-free survival respectively. Pooling of data was done using the random effect model. Results: 30 studies were included in this meta-analysis (3,628 cases and 37,100 controls). PABC patients had a significantly higher risk of death compared to those with non-pregnancy-related breast cancer (pooled hazard ratio (pHR): 1.44; 95% CI [1.27-1.63]). The same results were encountered on restricting the analysis to HRs of multivariate analyses (pHR: 1.40 [1.17-1.67]). A clearer trend of poorer outcome was seen in those diagnosed postpartum (pHR: 1.84; 95% CI [1.28-2.65]) than those diagnosed during pregnancy (pHR: 1.29; 95% CI [0.74-2.24]). DFS analysis showed a significantly higher risk of relapse associated with PABC as well (pHR: 1.60 [1.19-2.16]). Conclusion: Our results show that PABC is independently associated with poor survival particularly those diagnosed shortly post-partum. This underscores a possible impact of the pregnant breast microenvironment on the biology and consequently the prognosis of these tumors. © 2012 Elsevier Ltd. | en |
dc.language.iso | eng | en |
dc.source | Cancer treatment reviews | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Breast cancer | en |
dc.subject | Breast neoplasms | en |
dc.subject | Cancer patient | en |
dc.subject | Female | en |
dc.subject | Cancer survival | en |
dc.subject | Disease-free survival | en |
dc.subject | Prognosis | en |
dc.subject | Disease free survival | en |
dc.subject | Review | en |
dc.subject | Neoplastic | en |
dc.subject | Pregnancy complications | en |
dc.subject | Puerperium | en |
dc.subject | Cancer mortality | en |
dc.subject | Cancer relapse | en |
dc.subject | Overall survival | en |
dc.subject | Breast cancer during lactation | en |
dc.subject | Cancer prognosis | en |
dc.subject | Case-control studies | en |
dc.subject | Confidence interval | en |
dc.subject | Hazard ratio | en |
dc.subject | Information retrieval | en |
dc.subject | Multivariate analysis | en |
dc.subject | Outcome assessment | en |
dc.subject | Pregnancy | en |
dc.subject | Pregnancy associated breast cancer | en |
dc.subject | Relapse | en |
dc.subject | Survival | en |
dc.subject | Survival rate | en |
dc.subject | Tumor microenvironment | en |
dc.title | Prognosis of pregnancy-associated breast cancer: A meta-analysis of 30 studies | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.ctrv.2012.06.004 | |
dc.description.volume | 38 | |
dc.description.issue | 7 | |
dc.description.startingpage | 834 | |
dc.description.endingpage | 842 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Pentheroudakis, George [0000-0002-6632-2462] | |
dc.contributor.orcid | Peccatori, Fedro A. [0000-0001-8227-8740] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-6632-2462 | |
dc.gnosis.orcid | 0000-0001-8227-8740 |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |