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dc.contributor.authorChristaki, Eirinien
dc.contributor.authorGiamarellos-Bourboulis, Evangelos J.en
dc.creatorChristaki, Eirinien
dc.creatorGiamarellos-Bourboulis, Evangelos J.en
dc.date.accessioned2018-06-22T09:52:49Z
dc.date.available2018-06-22T09:52:49Z
dc.date.issued2014
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41521
dc.description.abstractThere is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered a rather homogeneous population. However, there is probably more individual variability between septic patients than previously considered. The pathophysiology of sepsis is a complex and dynamic process that originates from the host immune response to infection and varies according to the genetic predisposition, immune status and co-morbid conditions of the host, the type of pathogen and the site and extent of infection. Until now, efforts to stratify septic patients according to their immune profile were hampered by the lack of specific biomarkers. Recent advances in molecular medicine have made it possible to develop tools that will facilitate a faster and more precise diagnosis of infection. Individual variability between each patient's responses to infection can assist in tailoring therapeutic interventions to the individual's disease profile and monitoring treatment response. In this review, we describe those recent advances in genomics and theragnostics, which are slowly entering clinical practice and which will make possible a more personalized approach to each septic patient in the next decade. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 86 1 July 2014 10.1111/cge.12368 REVIEW REVIEWS © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.en
dc.language.isoengen
dc.sourceClinical geneticsen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectPriority journalen
dc.subjectReviewen
dc.subjectCancer diagnosisen
dc.subjectAntibiotic agenten
dc.subjectClinical practiceen
dc.subjectMeta analysis (topic)en
dc.subjectGenetic predisposition to diseaseen
dc.subjectBiological markersen
dc.subjectProceduresen
dc.subjectRandomized controlled trial (topic)en
dc.subjectBiological markeren
dc.subjectPathophysiologyen
dc.subjectEarly diagnosisen
dc.subjectImmunologyen
dc.subjectAntibiotic therapyen
dc.subjectGene expression profilingen
dc.subjectGenetic predispositionen
dc.subjectGeneticsen
dc.subjectGenomicsen
dc.subjectIndividualized medicineen
dc.subjectMetabolomicsen
dc.subjectMicrobiologyen
dc.subjectMonitoringen
dc.subjectPersonalized medicineen
dc.subjectSepsisen
dc.subjectSeptic shocken
dc.subjectSingle nucleotide polymorphismen
dc.subjectTranscriptomicsen
dc.subjectTrendsen
dc.titleThe beginning of personalized medicine in sepsis: Small steps to a bright futureen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/cge.12368
dc.description.volume86
dc.description.issue1
dc.description.startingpage56
dc.description.endingpage61
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidChristaki, Eirini [0000-0002-8152-6367]
dc.contributor.orcidGiamarellos-Bourboulis, Evangelos J. [0000-0003-4713-3911]
dc.gnosis.orcid0000-0002-8152-6367|0000-0003-4713-3911


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