dc.contributor.author | Dimou, Niki L. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Hamodrakas, Stavros J. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.creator | Dimou, Niki L. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Hamodrakas, Stavros J. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.date.accessioned | 2018-06-22T09:52:55Z | |
dc.date.available | 2018-06-22T09:52:55Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41567 | |
dc.description.abstract | Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcγ receptor (FcγR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials and Methods: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: FcγRIIA H131R (rs1801274), FcγRIIIA F158V (rs396991) and FcγRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: The FcγRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the FcγRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between FcγRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between FcγRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking). © 2010 John Wiley & Sons A/S. | en |
dc.language.iso | eng | en |
dc.source | Journal of clinical periodontology | en |
dc.subject | Fcγ receptor | el |
dc.subject | Models | en |
dc.subject | Meta-analysis | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Review | en |
dc.subject | Case-control studies | en |
dc.subject | Case control study | en |
dc.subject | Meta analysis | en |
dc.subject | Odds ratio | en |
dc.subject | Polymorphism | en |
dc.subject | Genetic | en |
dc.subject | Genetic polymorphism | en |
dc.subject | Biological model | en |
dc.subject | Receptors | en |
dc.subject | Risk | en |
dc.subject | Genetics | en |
dc.subject | Aggressive periodontitis | en |
dc.subject | Chronic periodontitis | en |
dc.subject | Fc receptor | en |
dc.subject | Igg | en |
dc.subject | Periodontitis | en |
dc.title | Fcγ receptor polymorphisms and their association with periodontal disease: A meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1111/j.1600-051X.2009.01530.x | |
dc.description.volume | 37 | |
dc.description.issue | 3 | |
dc.description.startingpage | 255 | |
dc.description.endingpage | 265 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |