Εμφάνιση απλής εγγραφής

dc.contributor.authorDimou, Niki L.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorHamodrakas, Stavros J.en
dc.contributor.authorBagos, Pantelis G.en
dc.creatorDimou, Niki L.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorHamodrakas, Stavros J.en
dc.creatorBagos, Pantelis G.en
dc.date.accessioned2018-06-22T09:52:55Z
dc.date.available2018-06-22T09:52:55Z
dc.date.issued2010
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41567
dc.description.abstractAim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcγ receptor (FcγR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials and Methods: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: FcγRIIA H131R (rs1801274), FcγRIIIA F158V (rs396991) and FcγRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: The FcγRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the FcγRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between FcγRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between FcγRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking). © 2010 John Wiley & Sons A/S.en
dc.language.isoengen
dc.sourceJournal of clinical periodontologyen
dc.subjectFcγ receptorel
dc.subjectModelsen
dc.subjectMeta-analysisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectReviewen
dc.subjectCase-control studiesen
dc.subjectCase control studyen
dc.subjectMeta analysisen
dc.subjectOdds ratioen
dc.subjectPolymorphismen
dc.subjectGeneticen
dc.subjectGenetic polymorphismen
dc.subjectBiological modelen
dc.subjectReceptorsen
dc.subjectRisken
dc.subjectGeneticsen
dc.subjectAggressive periodontitisen
dc.subjectChronic periodontitisen
dc.subjectFc receptoren
dc.subjectIggen
dc.subjectPeriodontitisen
dc.titleFcγ receptor polymorphisms and their association with periodontal disease: A meta-analysisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/j.1600-051X.2009.01530.x
dc.description.volume37
dc.description.issue3
dc.description.startingpage255
dc.description.endingpage265
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBagos, Pantelis G. [0000-0003-4935-2325]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0003-4935-2325


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής