Donor-derived breast cancer in a bone marrow transplantation recipient
dc.contributor.author | Golfinopoulos, Vassilis | en |
dc.contributor.author | Pentheroudakis, George | en |
dc.contributor.author | Kamakari, S. | en |
dc.contributor.author | Metaxa-Mariatou, V. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.creator | Golfinopoulos, Vassilis | en |
dc.creator | Pentheroudakis, George | en |
dc.creator | Kamakari, S. | en |
dc.creator | Metaxa-Mariatou, V. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.date.accessioned | 2018-06-22T09:53:14Z | |
dc.date.available | 2018-06-22T09:53:14Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41733 | |
dc.description.abstract | We present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified radical mastectomy for invasive breast adenocarcinoma. Genetic analysis revealed chimeric cellular populations on both the tumour and normal tissues of the patient with preponderance of donor-derived cells. We conclude that the patient's epithelia had been repopulated by donor-derived hemopoietic stem cells which gave rise to a malignant mammary neoplasm several years later. The donor remains healthy to date. This case adds weight to the theory of pluripotent normal and neoplastic stem cell histogenesis and emphasizes the pivotal role of supporting host stroma in carcinogenesis. © 2008 Springer Science+Business Media, LLC. | en |
dc.language.iso | eng | en |
dc.source | Breast cancer research and treatment | en |
dc.subject | Article | en |
dc.subject | Cyclophosphamide | en |
dc.subject | Cytarabine | en |
dc.subject | Human | en |
dc.subject | Adenocarcinoma | en |
dc.subject | Humans | en |
dc.subject | Transplantation | en |
dc.subject | Adult | en |
dc.subject | Breast neoplasms | en |
dc.subject | Female | en |
dc.subject | Neoplasm | en |
dc.subject | Priority journal | en |
dc.subject | Metastasis | en |
dc.subject | Neoplastic | en |
dc.subject | Acute granulocytic leukemia | en |
dc.subject | Idarubicin | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Lymphatic metastasis | en |
dc.subject | Breast cancer | en |
dc.subject | Case report | en |
dc.subject | Histopathology | en |
dc.subject | Mastectomy | en |
dc.subject | Cancer regression | en |
dc.subject | Whole body radiation | en |
dc.subject | Graft recipient | en |
dc.subject | Dna | en |
dc.subject | Adolescent | en |
dc.subject | Epidermal growth factor receptor 2 | en |
dc.subject | Genetic analysis | en |
dc.subject | Acute disease | en |
dc.subject | Alemtuzumab | en |
dc.subject | Allogenic bone marrow transplantation | en |
dc.subject | Bone marrow examination | en |
dc.subject | Bone marrow transplantation | en |
dc.subject | Breast adenocarcinoma | en |
dc.subject | Breast carcinogenesis | en |
dc.subject | Breast epithelium | en |
dc.subject | Cell differentiation | en |
dc.subject | Cell transformation | en |
dc.subject | Chimera | en |
dc.subject | Donor | en |
dc.subject | Echomammography | en |
dc.subject | Epithelial cells | en |
dc.subject | Hematopoietic stem cell | en |
dc.subject | Hematopoietic stem cells | en |
dc.subject | Homologous | en |
dc.subject | Leukemia | en |
dc.subject | Living donors | en |
dc.subject | Myeloid | en |
dc.subject | Neoplastic stem cells | en |
dc.subject | Pluripotent stem cells | en |
dc.subject | Short tandem repeat | en |
dc.subject | Stromal cells | en |
dc.subject | Transplantation conditioning | en |
dc.title | Donor-derived breast cancer in a bone marrow transplantation recipient | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s10549-008-9922-7 | |
dc.description.volume | 113 | |
dc.description.issue | 2 | |
dc.description.startingpage | 211 | |
dc.description.endingpage | 213 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Pentheroudakis, George [0000-0002-6632-2462] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-6632-2462 |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |