Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors
Date
2017Author
Szucs, Z.Thway, K.
Fisher, Cyril
Bulusu, Ramesh
Constantinidou, Anastasia
Benson, Charlotte
Graaf, W. T. A. van der
Jones, Robin Lewis
Source
Future OncologyVolume
13Issue
2Pages
185-194Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase clinical trials novel systemic treatments are currently being evaluated to target both the well explored and novel emerging downstream effectors of KIT and PDGFRA signaling. Alternative therapeutic approaches also include exploring novel inhibitors of the KIT/PDGFRA receptors, immune checkpoint and cyclin-dependent kinase inhibitors. The final clinical trial outcome data for these agents are highly anticipated. Integration of new diagnostic techniques into routine clinical practice can potentially guide tailored delivery of agents in the treatment of a highly polyclonal, heterogeneous disease such as heavily pretreated advanced gastrointestinal stromal tumor. © 2016 Robin L Jones.