dc.contributor.author | Tsantes, Argirio E. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Tsiara, Chrissa G. | en |
dc.contributor.author | Kapsimali, Violetta | en |
dc.contributor.author | Travlou, Anthi S. | en |
dc.contributor.author | Vaiopoulos, G. | en |
dc.creator | Tsantes, Argirio E. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Tsiara, Chrissa G. | en |
dc.creator | Kapsimali, Violetta | en |
dc.creator | Travlou, Anthi S. | en |
dc.creator | Vaiopoulos, G. | en |
dc.date.accessioned | 2018-06-22T09:53:22Z | |
dc.date.available | 2018-06-22T09:53:22Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41798 | |
dc.description.abstract | This study investigated the hypothesis that the insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor type-1 gene affects the risk for ischemic stroke, since results concerning this association have been controversial. We therefore performed a meta-analysis of published data regarding this issue. A comprehensive electronic search was carried out until January 2006. The analysis was performed using random-effects models and meta-regression. Eighteen eligible studies were retrieved (15 case-control studies and three cohort studies). The case-control studies included 3104 cases and 4870 control individuals concerning the contrast of 4G/4G versus remaining genotypes. The 4G pooled allele frequencies in cases and controls were 54.21 and 54.75%, respectively. Overall, the per-allele odds ratio of the 4G allele was 0.98 (95% confidence interval, 0.858-1.121). Regarding genotypes, we derived nonsignificant odds ratios in all contrasts. The subanalysis including the three studies with a prospective design in the 4G/4G versus 5G/5G contrast derived a significant result (relative risk, 0.523; 95% confidence interval, 0.353-0.775), but the estimated effect size was insignificant when cohort and case-control studies were analyzed together (relative risk, 0.848; 95% confidence interval, 0.662-1.087). We failed to demonstrate a significant association between the 4G/5G polymorphism and ischemic stroke under basal conditions. Determination of plasminogen activator inhibitor type-1 function seems of much higher clinical value than determination of the 4G/5G polymorphism. The effect of this genotype on risk of ischemic stroke in acute stressful diseases and the role of cohort studies in genetic epidemiology, however, warrant further investigation. © 2007 Lippincott Williams & Wilkins, Inc. | en |
dc.language.iso | eng | en |
dc.source | Blood Coagulation and Fibrinolysis | en |
dc.subject | Article | en |
dc.subject | Female | en |
dc.subject | Male | en |
dc.subject | Meta-analysis | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Priority journal | en |
dc.subject | Case-control studies | en |
dc.subject | Gene frequency | en |
dc.subject | Genotype | en |
dc.subject | Polymorphism | en |
dc.subject | Genetic | en |
dc.subject | Genetic polymorphism | en |
dc.subject | Risk factors | en |
dc.subject | Gene deletion | en |
dc.subject | Genetic risk | en |
dc.subject | Cohort studies | en |
dc.subject | Protein function | en |
dc.subject | 4g/5g polymorphism | en |
dc.subject | Plasminogen activator inhibitor 1 | en |
dc.subject | Cerebrovascular accident | en |
dc.subject | Ischemic stroke | en |
dc.subject | Stroke | en |
dc.subject | Gene insertion | en |
dc.subject | Brain infarction | en |
dc.subject | Genetic epidemiology | en |
dc.subject | Plasminogen activator inhibitor type-1 | en |
dc.subject | Plasminogen activators | en |
dc.title | Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: A meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1097/MBC.0b013e3281ec4eee | |
dc.description.volume | 18 | |
dc.description.issue | 5 | |
dc.description.startingpage | 497 | |
dc.description.endingpage | 504 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |